Cells taken from the edge of a healthy cornea can become a magic bullet to repair a previously considered irreparable cornea in the opposite eye report Harvard ophthalmologists. #cornea #stemcells #limbus #calec
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Howard G. Smith MD, AM on Instagram: "Cells From One Eye Can Heal The Other Cells taken from the edge of a healthy cornea can become a magic bullet to repair a previously considered irreparable cornea in the opposite eye. Ophthalmologists at Harvard’s Mass. Eye and Ear Infirmary developed what they term the CALEC procedure, an acronym for Cultivated Autologous Limbal Epithelial Cells. The limbal region of the cornea contains stem cells that constantly renew the corneal surface. These cells are harvested and grown out into a tissue graft in a laboratory at Boston’s Dana-Farber Cancer Institute. The graft is then implanted in the diseased eye. The researchers report their preliminary trial of 14 patients in the journal Nature Communications. The procedure boasts a 93% success rate for significant corneal repair with 79% of the subjects enjoying complete restoration of their injured corneas by 1 year postoperatively. After additional trials are complete, this procedure will be ready to restore sight in eyes once considered hopelessly blinded…. Someday soon. https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/calec-stem-cell-therapy-clinical-trial-repairs-corneal-damage #cornea #stemcells #limbus #calec"

0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Cells From One Eye Can Heal The Other Cells taken from the edge of a healthy cornea can become a magic bullet to repair a previously considered irreparable cornea in the opposite eye. Ophthalmologists at Harvard’s Mass. Eye and Ear Infirmary developed what they term the CALEC procedure, an acronym for Cultivated Autologous Limbal Epithelial Cells. The limbal region of the cornea contains stem cells that constantly renew the corneal surface. These cells are harvested and grown out into a tissue graft in a laboratory at Boston’s Dana-Farber Cancer Institute. The graft is then implanted in the diseased eye. The researchers report their preliminary trial of 14 patients in the journal Nature Communications. The procedure boasts a 93% success rate for significant corneal repair with 79% of the subjects enjoying complete restoration of their injured corneas by 1 year postoperatively. After additional trials are complete, this procedure will be ready to restore sight in eyes once considered hopelessly blinded…. Someday soon. https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/calec-stem-cell-therapy-clinical-trial-repairs-corneal-damage #cornea #stemcells #limbus #calec".

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La terapia CALEC è una svolta epocale per chi ha perso la vista a causa di danni corneali. Prelevando cellule staminali dall'occhio sano per rigenerare quello danneggiato, ha raggiunto un impressionante tasso di successo del 92% nei pazienti trattati. Dopo due decenni di ricerca, una procedura che ridà letteralmente la luce a chi viveva nel buio.

#CALEC #Staminali #Cornea #Medicina #Vista

https://www.futuroprossimo.it/2025/03/e-luce-fu-calec-rida-la-vista-ai-pazienti-con-danni-alla-cornea/

E luce fu: CALEC ridà la vista ai pazienti con danni alla cornea

La terapia CALEC con cellule staminali ha ripristinato la vista in 14 pazienti con danni corneali considerati incurabili.

Futuro Prossimo

If you like podcasts, check this out: "Deep Dive: Bright lights, big, LED cities" https://podcasts.apple.com/de/podcast/deep-dive-bright-lights-big-led-cities/id80106872?i=1000679467063

#DeutscheWelle reporter Kathleen Schuster interviewed me and Jana Eccard (from @unipotsdam) about #LightPollution.

Among other things, we take a walk through #Köln, and talk about our #CALEC project, where we made maps of the light emissions from the city.

Deep Dive: Bright lights, big, LED cities

Podcast-Folge · Living Planet · 06.12.2024 · 30 Min.

Apple Podcasts

This is awesome: the light beam from cars with LED headlights aren't visible in our infrared aerial photos of Köln in the #CALEC project. (Mouse-over to make the gif go)

Also, periodic reminder that German freeways almost never have streetlights.

What a difference two hours makes! These photos of Cologne, Germany were taken just under two hours apart during a flight of the #CALEC project (funded by Stadt Köln).

Our only global view of Earth at night is taken around 1:30 am. How much light does it miss?

The center of Cologne, Germany, imaged in 5 different wavelength bands: ultraviolet, visible (red, green, and blue), and infrared.

The differences between the photos come about because of the different lighting technologies. Orange high pressure sodium has a strong infrared signal, while white LED is only in the visible band.

I'm not sure yet what the UV emissions are, but they're probably from metal halide lamps.

Imaged during the #CALEC project funded by the City of Köln.