Cryo-electron tomography of RNA virus replication

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Cryo-electron tomography of RNA virus replication

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Cryo-electron tomography of RNA virus replication

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Cryo-electron tomography of RNA virus replication

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Toxic lover: Genetically engineering males to have venomous semen could wipe out disease-carrying insects

One way to shrink populations of disease-carrying pests is known as the sterile insect technique: Basically, you release tons of sterile males to mate with fertile females, preventing them from successfully adding to the next generation. While the method can work well, it requires enough males to be released to flood the mating market. In addition, fruitlessly mated females can still transmit disease until they die. Now, researchers have found a way to up the efficiency: Instead of males’ semen lacking viable sperm, it contains lethal toxins from a venomous animal.

When researchers tested the approach on fruit flies, they found that toxins from anemones and Brazilian wandering spiders were most effective, reducing the median lifespans of mated female flies by up to 64%. Additional modeling they performed suggested such mortality would reduce female mosquito populations faster than other approaches and lower blood feeding by as much as 60%. Even better, because these venom toxins are more molecularly targeted than broad-spectrum insecticides, the animals are unlikely to develop resistance to them, the team claims.

They aim to test the idea in mosquitoes next, and if all goes well, such “toxic males” could be deployed in as little as five years.
#mosquitoes #insects #arboviruses #ecology https://www.nature.com/articles/s41467-024-54863-1

Recombinant venom proteins in insect seminal fluid reduce female lifespan - Nature Communications

Current methods for genetic biocontrol of insect pests (e.g. gene drives) take generations to reduce harm. Here, authors engineered male fruit flies to express venom proteins in their seminal fluid that reduce female lifespan after mating, demonstrating a rapid approach to sustainable pest control.

Nature

#Household #expenditure on control of #urban #mosquitoes #Aedes albopictus and #Culex pipiens in #Emilia-Romagna, Northern #Italy https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012552

Control activities that lower the #mosquito #density in both private and public areas could reduce the use of household #insecticides in urban environments and the related costs, and the risk of spread of imported #arboviruses as well.

Household expenditure on control of urban mosquitoes Aedes albopictus and Culex pipiens in Emilia-Romagna, Northern Italy

Author summary To achieve effectiveness, mosquito control requires the adoption of integrated pest management (IPM) methods and comprehensive strategies in both public and private areas. In the case of urban mosquitoes, the application of IPM in public areas alone may not reduce the insect population density to levels that limit the nuisance, particularly during daytime, and mitigate the risks of arbovirus outbreaks. In Italy, the control activities by local administrations are usually limited to public areas, while interventions in private areas are delegated to owners and residents. This study analyzed the expenses incurred by households to protect themselves from mosquitoes. We found that the average yearly cost per household was about € 84.63 (excluding the depreciation costs of mosquito nets, the average expenditure drops to € 58.63 per household), which was significantly higher than the average expenditure incurred by local administrations for their interventions in public areas (approximately € 3/household/year). The efficacy of domestic mosquito control methods is difficult to estimate due to the variety of strategies, tools and operating conditions. Moreover, the application of domestic tools is mainly driven by marketing instead of sound cost-effectiveness evaluations.

World Health Organization (WHO): WHO launches global strategic plan to fight rising dengue and other Aedes-borne arboviral diseases…

The World Health Organization (WHO) launched the Global Strategic Preparedness, Readiness and Response Plan (SPRP) to tackle dengue and other Aedes-borne arboviruses... who.int/news #WHO #worldhealthorganisation #health #publichealth #dengue #arboviruses

https://formuchdeliberation.wordpress.com/2024/10/03/world-health-organization-who-who-launches-global-strategic-plan-to-fight-rising-dengue-and-other-aedes-borne-arboviral-diseases/

World Health Organization (WHO): WHO launches global strategic plan to fight rising dengue and other Aedes-borne arboviral diseases…

The World Health Organization (WHO) launched the Global Strategic Preparedness, Readiness and Response Plan (SPRP) to tackle dengue and other Aedes-borne arboviruses… who.int/news #WHO #world…

for much deliberation

Pernambuco registra os primeiros casos da Febre Oropouche, informa SES; saiba como se prevenir
Amostras dos exames identificaram um homem e uma mulher de Rio Formoso, município da Mata Sul de Pernambuco, com a doença
Por Portal Folha de Pernambuco

22/05/24

https://www.folhape.com.br/noticias/ses-pe-alerta-para-primeiros-casos-da-febre-do-oropouche-em-pernambuco/337578/

#Brasil
#Arboviruses
#Portugues_br

Pernambuco registra os primeiros casos da Febre Oropouche, informa SES; saiba como se prevenir

Amostras dos exames identificaram um homem e uma mulher de Rio Formoso, município da Mata Sul de Pernambuco, com a doença

Understanding Arboviruses: A Threat to Human Health

#Arboviruses, #Dengue, #DengueFever, #LymeDisease, #Virus, #VirusInfection, #ZikaVirus #Virology Introduction: Arboviruses, short for arthropod-borne viruses, constitute a group of viruses that primarily rely on arthropods, such as mosquitoes and…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/05/14/understanding-arboviruses-a-threat-to-human-health/

Understanding Arboviruses: A Threat to Human Health

#Arboviruses, #Dengue, #DengueFever, #LymeDisease, #Virus, #VirusInfection, #ZikaVirus #Virology Introduction: Arboviruses, short for arthropod-borne viruses, constitute a group of viruses that pri…

Medical Microbiology & RDT Labs