📖 Vaidya et al. investigate how #hippocampal #CA1 #PlaceCells form expanding #memory representations over days. Using longitudinal in vivo recordings, they show that stable #PlaceFields progressively emerge as active cells increase their likelihood of remaining active across sessions. This gradual stabilization hinges on #behavioral‑timescale #SynapticPlasticity, offering a new model of how CA1 memories solidify w/o #CatastrophicOverwriting.

🌍 https://www.nature.com/articles/s41593-025-01986-3

#Hippocampus #Neuroscience

Formation of an expanding memory representation in the hippocampus - Nature Neuroscience

Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel mechanisms of hippocampal memory formation.

Nature

And as an added bonus: Dileep George, one of the authors of the paper, just shared a #JupyterNotebook demo 🐍📔. You can explore the #CSCG model, visualize #PlaceFields, and inspect the learned #latent #graphs 📈 Just try it out, it's great fun 👌

🌍 https://colab.research.google.com/drive/1kgjuoz_Noo7uV87StSbW7T8-IBQmPOLE?usp=sharing#scrollTo=7jnInNH7RUAX

#Hippocampus #CognitiveMaps #CSCG #Neuroscience #ComputationalModeling #CompNeuro

Google Colab

This paper by Raju et al. proposes a unified model – “clone‑structured causal #graphs” (#CSCG) – for #hippocampal #SpatialCoding. It suggests that #SpatialMaps arise from #learning #latent higher‑order sequences rather than representing #EuclideanSpace directly. The model elegantly explains phenomena like #PlaceFields, #SplitterCells, #contextual #remapping, and predicts when #PlaceFieldMapping may mislead.

🌍 https://www.science.org/doi/10.1126/sciadv.adm8470

#Hippocampus #CognitiveMaps #SequenceLearning #Neuroscience

New review on the “spatial cells” across different species! Looks very interesting:
Neural mechanisms for spatial cognition across vertebrates
Vinepinsky & Segev 2023

Small but important comment: it is perfectly normal for place cells to have multiple #PlaceFields ! Only in very small environments (<80cm diameter) will you mostly see single-field place cells. The single field is probably more the exception than the rule in the natural world.

#NeuroPaper #Review #Neuroscience #PlaceCells #HeadDirectionCells #GridCells #BVCs #CrossSpecies

@shannonmattern Thank you. More improv, please. This piece got me hooked. Illuminating and very helpful to my family as we work to take care of my Father in late stage dementia. Place neurons. Place fields.

https://placesjournal.org/article/architectural-and-urban-design-for-dementia-care/

#PlaceFields #Volumes

Concealment and Compassion

Dementia care is usually marginalized in remote asylums, informal networks, or grim nursing homes. Why can’t entire buildings and whole cities be designed as caring environments writ large?

Places Journal