๐ง Synaptic plasticity is how your brain physically encodes memory. And its decline may be at the core of cognitive aging.
#Neuroscience #SynapticPlasticity #AgingResearch #Longevity #MolecularBiology #Neurology #BrainHealth #Hallmarks #CognitiveDecline #LifeSciences
๐ง New preprint by Zhong et al. proposes a #synaptic mechanism for #chunking in #WorkingMemory.
Using short-term #plasticity and synaptic augmentation, their model shows how items can be temporarily suppressed and later retrieved as chunks, increasing effective capacity w/o increasing simultaneous activity.
๐ Could a protein that twists into filaments reveal how cells keep themselves in balance?
๐ Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.018
๐ CSBJ: https://www.csbj.org/
#StructuralBiology #CryoEM #Thorase #MolecularBiology #mTORC1 #ProteinStructure #Biophysics #AAAplusATPase #SynapticPlasticity #Mitochondria
The Brainโs Rewiring Power: Understanding Activity-Dependent Synaptic Changes
#BrainScience #Neuroplasticity #MemoryAndLearning #Neuroscience #BrainHealth #SynapticPlasticity #MindAndBrain #NeuralNetworks #CognitiveScience #BrainRecovery
From Neurotransmitters to Kinases: The Chemistry Powerhouse of Your Brain
#BrainChemistry #Neuroscience #Neurobiology #BrainFacts #SynapticPlasticity #Neurotransmitters #ProteinKinaseC #MemoryAndLearning #BrainHealth #ScienceExplained
How Your Brain Forms Memories: The Science of Synaptic Plasticity
#BrainScience #Neuroscience #Memory #Learning #SynapticPlasticity #Neurons #BrainHealth #LTP #Neurobiology #MindAndBrain
๐ Vaidya et al. investigate how #hippocampal #CA1 #PlaceCells form expanding #memory representations over days. Using longitudinal in vivo recordings, they show that stable #PlaceFields progressively emerge as active cells increase their likelihood of remaining active across sessions. This gradual stabilization hinges on #behavioralโtimescale #SynapticPlasticity, offering a new model of how CA1 memories solidify w/o #CatastrophicOverwriting.
Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel mechanisms of hippocampal memory formation.
"A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses", Chipman et al. 2025 (Graeme Davis lab).
https://www.cell.com/neuron/fulltext/S0896-6273(25)00430-1. (Open access)
"Sema3a-PHP redistributes vesicles from a non-releasing to the release-ready pool"
Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Hereโs a summary from our JC:
๐ https://www.fabriziomusacchio.com/blog/2025-06-29-astrocyte_enhance_plasticity/
๐ https://doi.org/10.1038/s42003-024-06540-8
Alice Frolov
Fabrizio Musacchio
PLOS Biology
CSBJ
CITO Greenhouse
Fabrizio Musacchio
Albert Cardona