Fabrizio Musacchio📖 Vaidya et al. investigate how #hippocampal #CA1 #PlaceCells form expanding #memory representations over days. Using longitudinal in vivo recordings, they show that stable #PlaceFields progressively emerge as active cells increase their likelihood of remaining active across sessions. This gradual stabilization hinges on #behavioral‑timescale #SynapticPlasticity, offering a new model of how CA1 memories solidify w/o #CatastrophicOverwriting.
Formation of an expanding memory representation in the hippocampus - Nature Neuroscience
Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel mechanisms of hippocampal memory formation.