Another day, another new feature in #LabPlot - #BaselineCorrection (#arPLS) as an #analysis curve on the plot. 🎁
#MerryChristmas! We hope Santa is good to you this year!🎅 🎄
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#OpenSource #FreeSoftware #FLOSS #FOSS #DataViz #DataAnalysis #KDE #BaselineRemoval #BackgroundCorrection #NoiseRemoval #XRD #FTIR #RamanSpectrum #SignalProcessing #Spectroscopy #PeakAnalysis #MaterialsScience #Chemistry #Nanomaterials #Tech #Technology
🧬 Could a single residue swap turn a life-saving antibody into a “dead mutant”?
🔗 Replacement of a single residue in an antibody abolishes cognate antigen binding, as predicted by theoretical methods. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.018
📚 CSBJ: https://www.csbj.org/
#AntibodyEngineering #StructuralBiology #ComputationalBiology #ProteinModeling #Biophysics #Diagnostics #MolecularDynamics #MolecularSimulation #InfraredSpectroscopy #FTIR
Abstract Biosynthesized metal nanoparticles have unique properties and are being actively studied as potential antimicrobial agents against resistant pathogens. The “green” synthesis of silver nanoparticles and their conjugate with the antibiotic ceftriaxone, carried out using the aqueous extract of Chaenomeles japonica leaves as a biological matrix, is reported here for the first time. UV-visible spectra confirmed the creation of biosynthesized silver nanoparticles (Ch-AgNPs) and their conjugates with ceftriaxone (Ch-AgNPs-Cfx), which were characterized by surface plasmon resonance absorption peaks at 475 and 478 nm, respectively. Fourier transform infrared spectrum analysis revealed the participation of hydroxyl and carboxyl functional groups of phenolic and aromatic compounds, flavonoids, terpenoids, alcohols, and carboxylic acids of the plant extract in the process of bioreduction of Ag+ to Ag0 as well as the involvement of carbonyl and amine groups of proteins in blocking and stabilization silver nanoparticles. The antimicrobial activity of Ch-AgNPs, Ch-AgNPs-Cfx, and ceftriaxone was evaluated using a disk diffusion assay against Pseudomonas aeruginosa strain resistant to some cephalosporins. Studies have shown a dose-dependent inhibition of P. aeruginosa by Ch-AgNPs and Ch-AgNPs-Cfx in the range of 2.5–20 μg/disk, which exceeded the activity of ceftriaxone at the same doses, which characterizes both types of biosynthesized nanoparticles as promising bactericidal agents. Further research on Ch-AgNPs and Ch-AgNPs-Cfx may be aimed at creating effective means to reduce the antibiotic doses without losing antibacterial activity against resistant pathogens.
New publication on NO₂ amount fraction measurement using #FTIR. Our approach allowed us to to quantify impurities like N₂O and nitric acid. The focus was on exhaust emission using #PEMS.
https://kumulonimb.us/publicaciones/reviewed/2025-kim/
Looking for #advice for trying to correct #ATR #FTATR #spectrum using #R / #rstudio .
I need to make my #spectra comparable to #OPTIR but I can’t figure out the #coding for #ATRcorrection 😭.
Note: I don’t need to do #baselinecorrection as such, more about #weighting :)
One of the weird things about #FTIR spectroscopy is that because it is so well developed and optimized a lot of the complications are kinda hidden away inside the very polished and optimized instruments.... until they suddenly jump out and bite you in the ass.
So today I rediscovered something about #FTIR and resolution that I 100% read in a text book a decade ago and then forgot.
LabPlot (labplot.org)
CSBJ
CVUA Stuttgart
Cytology and Genetics
Jorge Saturno
Laura Scoble
Georg Ramer