PlanetMedicinesOct 21, 2023
An open-label study evaluating the safety, behavioral, and electrophysiological outcomes of low-dose #ketamine in children with ADNP syndrome (2022)- ScienceDirect https://www.sciencedirect.com/science/article/pii/S2666247722000549 #autism #ADNP #ketaminetherapy #psychedelics #research
Toyooka LabOct 13, 2023

In the current issue of Molecular Psychiatry, the ADNP protein image from our previous publication has been published.

https://doi.org/10.1038/s41380-023-02119-7

https://rdcu.be/dovsz

Below is the link to the original article describing the functions of ADNP and 14-3-3epsilon on neuronal morphogenesis and neural connectivity during the development of the cortex.

https://nature.com/articles/s41380-022-01939-3

#autism #ADNP #Ywhae #neuriteformation #spineformation #synapseformation #neuralconnection #neuralcircuit
#neuralactivity #neurodevelopment #cortex #brain #neuroscience

Autism News InternationalJan 25, 2023
Going on Trial: Arbaclofen reboot; cell implants; psilocybin microdoses

https://www.spectrumnews.org/news/going-on-trial-arbaclofen-reboot-cell-implants-psilocybin-microdoses/

#fragileXsyndrome #clinicaltrials #goingontrial #arbaclofen #epilepsy #seizures #autism #News #ADNP #GABA
Going on Trial: Arbaclofen reboot; cell implants; psilocybin microdoses | Spectrum | Autism Research News

Going on Trial rounds up new developments in autism-related drug trials. This month we’re revisiting decade-old data from a trial of arbaclofen for fragile X syndrome and looking into a new implant-based approach to quelling seizures, among other treatment strategies.

Spectrum | Autism Research News
Autism News InternationalJun 9, 2022
Two top autism-linked proteins connect to build cell ‘skeleton’

https://www.spectrumnews.org/news/two-top-autism-linked-proteins-connect-to-build-cell-skeleton/

#schizophrenia #genenetworks #mousemodels #treatments #dendrites #synapses #autism #SHANK3 #News #ADNP
Two top autism-linked proteins connect to build cell ‘skeleton’ | Spectrum | Autism Research News

ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.

Spectrum | Autism Research News
Autism News InternationalJan 10, 2022
Top autism-linked gene boosts DNA accessibility during development

https://www.spectrumnews.org/news/top-autism-linked-gene-boosts-dna-accessibility-during-development/

#geneexpression #chromatin #autism #News #ADNP
Top autism-linked gene boosts DNA accessibility during development | Spectrum | Autism Research News

Loss of the POGZ gene in mice makes certain genes inaccessible and prevents their expression.

Spectrum | Autism Research News
Autism News InternationalNov 3, 2021
Sex bias emerges in new mouse model with autism-linked mutation

https://www.spectrumnews.org/news/sex-bias-emerges-in-new-mouse-model-with-autism-linked-mutation/

#developmentaldelay #socialdeficits #mousemodels #biomarkers #autism #News #ADNP #sex
Sex bias emerges in new mouse model with autism-linked mutation | Spectrum | Autism Research News

Compared with a previous mouse strain, a new model better reflects some of the difficulties that people with a rare autism-related syndrome experience, and may help identify biomarkers of the syndrome.

Spectrum | Autism Research News
Autism News InternationalJul 28, 2021
The push to screen newborns for rare autism-linked genetic conditions

https://www.spectrumnews.org/news/the-push-to-screen-newborns-for-rare-autism-linked-genetic-conditions/

#whole-genomesequencing #Prader-Willisyndrome #Angelmansyndrome #fragileXsyndrome #genetictesting #spokenversion #Rettsyndrome #sequencing #diagnosis #autism #News #ADNP
The push to screen newborns for rare autism-linked genetic conditions | Spectrum | Autism Research News

As treatments for some autism-linked genetic conditions inch closer to the clinic, researchers are talking more urgently about screening all newborns for such conditions.

Spectrum | Autism Research News
Autism News InternationalJul 14, 2021
Mapping the futures of autistic children

https://www.spectrumnews.org/features/deep-dive/mapping-the-futures-of-autistic-children/

#behavioralinterventions #intellectualdisability #repetitivebehavior #spokenversion #severeautism #motorskills #depression #treatments #education #DeepDive #language #anxiety #autism #DYRK1A #GRIN2B #SCN2A #ADNP #CHD8 #IQ
Mapping the futures of autistic children | Spectrum | Autism Research News

Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?

Spectrum | Autism Research News