Fishing for protein partners nets clues to autism

https://www.spectrumnews.org/news/fishing-for-protein-partners-nets-clues-to-autism/

#genenetworks #interactome #autism #News #ANK2 #PTEN

https://biorxiv.org/cgi/content/short/2023.01.18.524537v1
We show a positive correlation between the age of selective sweeps at genes in these network and their degree of connectivity. Should we interpret these findings as older sweeps occurring at more connected genes in a network during the adaptation to drought stress?
#adaptationgenomics #SelectiveSweep #GeneNetworks #Solanum

Multi-omics study captures CNTNAP2’s far-ranging effects

https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/

#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News

Two top autism-linked proteins connect to build cell ‘skeleton’

https://www.spectrumnews.org/news/two-top-autism-linked-proteins-connect-to-build-cell-skeleton/

#schizophrenia #genenetworks #mousemodels #treatments #dendrites #synapses #autism #SHANK3 #News #ADNP

Autism and the complete human genome: Q&A with Evan Eichler

https://www.spectrumnews.org/opinion/autism-and-the-complete-human-genome-qa-with-evan-eichler/

#whole-genomesequencing #copynumbervariation #denovomutations #geneexpression #genetictesting #genenetworks #rarevariants #epigenetics #15q11-13 #Opinion #16p11.2 #GWAS #QA