Asleep in the Mouse House with Graham Diering | Spectrum | Autism Research News
Memories from Diering’s life trace the rising star’s scientific path from raising lizards as a child and later exploring home brewing to heading a lab that investigates memory, sleep disturbances and early development in animals with autism-linked mutations.
One-rosette technique grows well-organized organoids | Spectrum | Autism Research News
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
Mouse models help sniff out olfactory differences in autism | Spectrum | Autism Research News
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Double SHANK knockout highlights brain circuit’s social role | Spectrum | Autism Research News
Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.
Lost sleep sparks lasting social problems in SHANK3 mice | Spectrum | Autism Research News
Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.
New software flags autism rat model’s telltale squeaks | Spectrum | Autism Research News
By breaking rodent vocalizations into parts, TrackUSF distinguishes rats with mutations in the SHANK3 gene from their wildtype counterparts.
Autism-linked mutation disrupts brain circuit to change social behavior | Spectrum | Autism Research News
Therapies that target the circuit could boost social activity, new findings suggest.
Poor sleep shifts social circuit in mice | Spectrum | Autism Research News
Even temporary bouts of too little non-REM sleep can lead to long-term changes in how the animals respond to certain social situations, new research suggests.
Two top autism-linked proteins connect to build cell ‘skeleton’ | Spectrum | Autism Research News
ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.
Heart anomalies abound in mouse models of autism | Spectrum | Autism Research News
Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.
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