Genetic risk for neurodevelopmental and psychiatric disorders may act less by deleting inhibitory neuron types than by biasing how they are made. This is the subject of our new review in Current Opinion in Genetics & Development (Dvoretskova & Mayer).
We draw on developmental genetics, lineage tracing, and human genetics. The main point: disease-linked variants often don't abolish particular inhibitory neuron types. Instead they shift developmental trajectories — timing, fate bias, lineage allocation — leaving subtype proportions imbalanced among otherwise normal cell types.
https://doi.org/10.1016/j.gde.2026.102504
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