Kilian Schober

86 Followers
66 Following
49 Posts

MD Microbiology, Virology, Infection Epidemiology. Understanding & Engineering Human T Cell Immunity at University Hospital of Erlangen.
Cycling. BVB. Cinema. Family.

www.schoberlab.de

Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness https://www.biorxiv.org/content/10.1101/2023.01.27.525946v1?med=mas
'Immune response to the vaccine mRNA is the most literal example of “killing the messenger” that I can think of, short of the Spartan treatment of Darius’ envoys in 491 BC.'
cc @Caroline_Bartma
https://www.science.org/content/blog-post/curevac-comes-around
CureVac Comes Around

Plenty of good vaccine news lately, unfortunately not regarding HIV: J&J just declared to discontinue their phase 3 HIV vaccine trial with a mosaic-based Ad26.
https://www.jnj.com/janssen-and-global-partners-to-discontinue-phase-3-mosaico-hiv-vaccine-clinical-trial
https://www.nih.gov/news-events/news-releases/experimental-hiv-vaccine-regimen-safe-ineffective-study-finds
Janssen and Global Partners to Discontinue Phase 3 Mosaico HIV Vaccine Clinical Trial | Johnson & Johnson

Independent, scheduled review of Phase 3 Mosaico study finds investigational vaccine regimen lacks efficacy in preventing HIVNo vaccine-related safety issues identified

Content Lab U.S.

My first post on Mastodon after a whole lot of lurking and boosting, so I'm treating this as a mini #introduction for myself

I'm an #immunology PhD candidate at #ColumbiaUniversity medical center, and we just published a study of #TissueSpecifity of human #Tcell identity and clonal expansion in barrier sites, using #CyTOF, #scRNAseq, and #TCR #sequencing!

https://www.nature.com/articles/s41590-022-01395-9

Tissue adaptation and clonal segregation of human memory T cells in barrier sites - Nature Immunology

Farber and colleagues examine the phenotypic, transcriptomic, clonal, and functional differences between tissue-resident T cells in various barrier tissue sites relative to T cells in lymphoid organs and circulation in humans.

Nature
#Influenza A, which started circulating at high levels earlier this season than in any season since the 2009 #H1N1 pandemic, is declining as quickly as it climbed. It is truly remarkable to see the map of #flu-like activity show so little red in the 2nd week of Jan. It is like this year's flu season shifted forward 2 months or so.
Last week on the right. Same week in 2018, on the left, as the 2017-18 season started to take off.

Happy to see this study out! Massive effort by our student Arien Schiepers and also many collaborators, both from our lab and @jbloom_lab, Paul Bieniasz (Rockefeller), and Norbert Pardi’s (U. Penn) groups.

https://www.nature.com/articles/s41586-023-05715-3

Molecular fate-mapping of serum antibody responses to repeat immunization - Nature

Serum antibody responses to sequential homologous booster vaccines derive overwhelmingly from primary cohort B cells at the expense of de novo responses; this ‘primary addiction’ can be overcome by boosting with variant antigens.

Nature
If you might be interested in reading some nuanced views on antigenic imprinting, please see this from @katherinejwu https://www.theatlantic.com/health/archive/2023/01/covid-vaccine-immunity-variant-protection/672704/. A better and more thoughtful read (with a lot of quotes from people who actually study this problem) than a certain NEJM commentary heavy on motivated reasoning.
Is COVID Immunity Hung Up on Old Variants?

You never forget your first time with SARS-CoV-2.

The Atlantic

We have an opening for 11 (!) #PhD students in a #MSCA training network. With a a great team working on #RNA-binding protein work, studying fundamental aspects and disease models #viral infection / #liver disease/ #immunology/ #cancer

. You find more information here:

https://euraxess.ec.europa.eu/jobs/51150

also searching for a #projectmanager in this EU network...
#RNA

EUROPE: 11 PhD positions in MSCA DN project RBP-ReguNET

Eleven PhD positions are available in the Marie Sklodowska-Curie Doctoral Network “RBP-ReguNET – Deconstructing and Rewiring RNA-RBP regulatory networks”.

EURAXESS
Hi @Quartzy - is it true that from July onwards you will be charging also academic labs for using your basic order tracking system ($79/5 users)? Do I remember your #freeforever pledge correctly? Thanks for clarifying. #AcademicChatter

RT @[email protected]

Thrilled to share the first Eyquem lab paper! Today we report in @[email protected] evolving the AAV6 capsid to enable efficient engineering of murine T cells. An exciting collab with @[email protected] and led by the brilliants @[email protected] and Jon Ark
https://www.cell.com/cell/fulltext/S0092-8674(22)01535-5#.Y8BZyEK6vsY.twitter 🧵1/11

🐦🔗: https://twitter.com/j_eyquem/status/1613704444499365890