This is a many-years study, started by Marleen Van Loenen, continued by Rosa de Groot, and now analysed and written up by Suzanne Castenmiller and Nandhini Kanagasabesan, w supported by Aurélie Guislain and Benoit Nicolet, PhD
Great collaboration with the medical team from the AvL-NKI, with
Koen Hartemink, Kim Monkhorst, Alexander Veenhof, Egbert Smit en John Haanen
Supported by Sanquin Blood Supply Foundation funding and Oncode Institute
Now In press!!!
We came to the surprising conclusion that (contrary to what is reported for responsiveness to immunotherapy), the tumor reactivity of TIL products negatively correlates with the amount of B cell/ naive T cell infiltrates in the tumor.
We also have a hypothesis as to why that is.
Interested? Check it our!
May I suggest getting a public library card?
I access almost all paywalled material for free via PressReader using my public library.
If you live in a red state, Brooklyn Public Library offers services to victims of GOP book bans & other attacks on literate citizenship. Ditto Boston Public Library.
Why are so many young people getting cancer?
Please find below our most recent pre-print. We studied the role of the RNA binding protein ZFP36L2 in effector T cells and found how it regulated the production of IFNgamma in late T cell responses and continuous activation with tumor cells (in vitro/in vivo). Happy reading!
https://www.biorxiv.org/content/10.1101/2024.02.09.579641v1.article-metrics
As much as i am horrified about the neo-fascist developments in Germany, i am just very proud of the citizens of my home country to step up and clarify that the 'silent' majority absolutely does NOT support this AfD rubbish, and that it starts speaking up. I very much hope that this is just the start for a Europe wide- what do I say - world wide movement for stepping up!
https://www.tagesschau.de/inland/gesellschaft/demonstrationen-gegen-rechts-sonntag-100.html
"Integrative analysis of #neuroblastoma by single-cell RNA sequencing identifies the #NECTIN2-#TIGIT axis as a target for #immunotherapy"
https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00436-1
Great new work from Judith Wienke et al. from the Molenaar lab in the #PrincessMaximaCenter in #Utrecht.
Great to see this out after seeing it in our group meetings several times. In vivo results sometimes are impressive, but very much in a subgroup it seems. Intriguiging, and curious what underlies this.
Hey all!
In the new year, I would like to help build a flourishing #science community for #Immunology and #ComputationalBiology (since those are my main #research interests 🤓🙂)
Looking to follow more researchers/hashtags for sharing our work, so hook me up (even if they haven't been active in a while)!
Also, I'm planning to post more computational/immunology content. Please let me know in the poll below about what types of content you'd be interested in!
Boosts appreciated!
Nicole Parsons
Marc Abrahams
Marieke van Vugt
Arjan Boltjes
Daniel Caron