Daniel CaronJan 20, 2023

My first post on Mastodon after a whole lot of lurking and boosting, so I'm treating this as a mini #introduction for myself

I'm an #immunology PhD candidate at #ColumbiaUniversity medical center, and we just published a study of #TissueSpecifity of human #Tcell identity and clonal expansion in barrier sites, using #CyTOF, #scRNAseq, and #TCR #sequencing!

https://www.nature.com/articles/s41590-022-01395-9

Tissue adaptation and clonal segregation of human memory T cells in barrier sites - Nature Immunology

Farber and colleagues examine the phenotypic, transcriptomic, clonal, and functional differences between tissue-resident T cells in various barrier tissue sites relative to T cells in lymphoid organs and circulation in humans.

Nature
Marc Robinson-RechaviNov 17, 2022
Very exciting preprint led by Manu Irimia on evolution of tissue-specificity of expression in vertebrates and insects, providing great data, evidence for "low conservation of tissue-specific expression profiles", and tissue-specific gains associated with duplications and with the emergence of unique phenotypes
https://www.biorxiv.org/content/10.1101/2022.11.14.516384v1
#geneexpression #EvolutionaryBiology #TissueSpecifity #ortholog #paralog #DeneDuplication