Mastodawn

Janet Kumita Feb 13, 2023

Patrick van der Wel Feb 11, 2023

New paper from the group of Mark Hipp (UMCG #Groningen) and collaborators: "The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system" About chaperones, disaggregases, #amyloid and more. Notes that fibril disaggregation can actually enhance #prion like spreading....
https://www.nature.com/articles/s41467-023-36058-2 #AlzheimerDisease

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system - Nature Communications

Tau aggregates are associated with several neurodegenerative disorders. In this work, I. Saha and colleagues show that valosin-containing protein (VCP) recruited to Tau fibrils disaggregates them. However, this process comes at a cost: it generates seeding-active Tau species as byproduct.

Nature

Janet Kumita Feb 13, 2023

bioRxiv biophysics Feb 11, 2023

📰 "The structural architecture of an α-synuclein toxic oligomer"
by 🔬 Santos, J., Cuellar, J., Pallares, I., Byrd, E. J., Lends, A., Moro, F., Abdul-Shukkoor, M. B., Pujols, J., Velasco-Carneros, L., Sobott, F., Otzen, D. E., Calabrese, A. N., Muga, A. et al.
#bioRxiv #biophysics http://biorxiv.org/cgi/content/short/2023.02.10.527650v1?rss=1

Janet Kumita Feb 9, 2023

CRAIG M CREWS Feb 9, 2023

Happy to share our latest #PhosTAC paper where we target #Tau for dephosphorylation. #chemicalbiology #heterobifunctional

https://pubs.acs.org/doi/10.1021/jacs.2c11706

Janet Kumita Jan 14, 2023

bioRxiv Jan 13, 2023

Design of amyloidogenic peptide traps https://www.biorxiv.org/content/10.1101/2023.01.13.523785v1?med=mas

Janet Kumita Dec 30, 2022

David Schnettler Dec 30, 2022

#introduction

Hi, I'm a biochemist enthusiastic about #enzymes, #biocatalysis and #ProteinEngineering & #ProteinEvolution.

I did my PhD with Florian Hollfelder at the #UniversityofCambridge working on #DirectedEvolution of enzymes using droplet #microfluidics. Currently, I am doing a postdoc at #ETHZurich, studying which properties determine a protein’s innovability towards new function.

Looking forward to learning about cool preprints/papers and finding a lively scientific community here!

Janet Kumita Dec 27, 2022

IDPseminars Dec 27, 2022

Hi all! #introduction

We are a virtual seminar series about all aspects of intrinsically disordered proteins (IDPs). Scientific fields include: #biophysics, #biochemistry, #cellbiology, #bioinformatics, #softmatterphysics etc.

Our new program is just out with seminars on the first Thursday of each week (CET 7PM, EST 1PM) .

IDPseminars are run by @Proteinmagnus and @alexholehouse

Janet Kumita Dec 27, 2022

Emmanuel Margeat Nov 22, 2022

Time for #introduction.
My name is Emmanuel « Manu » Margeat.
I develop and use single molecule fluorescence , including #smFRET, #FCS, and #SPT.
My research focuses on elucidating the structural dynamics and the interactions of #membrane #proteins, in vitro and in living cells.
I am strongly involved in research management, serving as deputy director of the #CBS, the Centre de Biologie Structurale in Montpellier , or as Council member for the french and the american Biophysical Society #BPS.

Janet Kumita Dec 23, 2022

Elias Adriaensssens Dec 23, 2022

Hello!

Time for an #introduction . I’m a postdoc with Sascha Martens at the Max Perutz Labs in Vienna.

I’m fascinated by protein quality control and autophagy.

Janet Kumita Dec 22, 2022

Magnus Kjaergaard Dec 22, 2022

It is often said that virtual scientific meetings lack the networking components of in-person conference.

At IDPseminars, we beg to differ. 😎

A story in three parts:

Janet Kumita Dec 21, 2022

TheVilchezLab Dec 13, 2022

I’m still not sure how this 🐘 works, but I guess the best is to start with an #introduction
Here I will be posting about stuff from our lab at the CECAD. We want to understand #aging and #proteostasis to prevent multiple age-related diseases such as #ALS, #Alzheimer, #Parkinson and #huntington