Orchestration of selective autophagy by cargo receptors: Current Biology
https://www.cell.com/current-biology/fulltext/S0960-9822(22)01758-4
Orchestration of selective autophagy by cargo receptors: Current Biology
https://www.cell.com/current-biology/fulltext/S0960-9822(22)01758-4
Hello!
Time for an #introduction . I’m a postdoc with Sascha Martens at the Max Perutz Labs in Vienna.
I’m fascinated by protein quality control and autophagy.
Check out also two back-to-back papers that describe homologous systems. One that describes the Bim1/Bik1/Kar9 system in budding yeast, and the mechanism of non-stoichiometric accumulation of Kar9 at a single microtubule end: https://www.nature.com/articles/s41556-022-01035-2
And the other, examining how specific mutations that disrupt in vitro phase separation of EB1 correlate with EB1's effects on microtubule dynamics and mitotic progression: https://www.nature.com/articles/s41556-022-01033-4
Our paper is published today after peer-review: https://www.nature.com/articles/s41556-022-01037-0
We asked whether protein complexes that follow growing microtubule ends are liquid condensates or not. The answer is not a simple yes or no, so give it a read if you are interested. I find these panels particularly informative
Maan et al., Meier et al. and Song et al. report that microtubule plus-tip end binding proteins can undergo liquid–liquid phase separation and regulate microtubule dynamics.
RT @EMBLEvents
Would you like to get some hands-on training on expansion microscopy (ExM)? 🔬 Join this 5-day EMBL Course and you'll be all set to use this powerful technique and apply it in your lab 👩🏾🔬 #EMBLExM
📥 Apply by 27 Feb
📅 22–26 May 2023
🗺️ EMBL Heidelberg
How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basis
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding