Elias Adriaensssens

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3 Following
23 Posts
Postdoc with Sascha Martens at Max Perutz Labs. #MSCA Fellow. Formerly University of Oxford and University of Antwerp. Interested in protein and organelle quality control.
Enjoy our @CurrentBiology review article just before the Christmas break! With @lucaferrari and @saschamartens .

Orchestration of selective autophagy by cargo receptors: Current Biology

https://www.cell.com/current-biology/fulltext/S0960-9822(22)01758-4

Hello!

Time for an #introduction . I’m a postdoc with Sascha Martens at the Max Perutz Labs in Vienna.

I’m fascinated by protein quality control and autophagy.

We are thrilled to announce that the outstanding mitochondrial probes PKmito ORANGE , RED and DEEP RED will be available at Spirochrome through its distributors network in January 2023.
PKmito probes are gentle to the cells and allow long term imaging as well as recording amazingly crisp STED images of mitochondrial cristae.
Read more about PKmito ORANGE in the fresh article from Zhixing Chen and Stefan Jakobs labs out in @PNASNews
https://www.pnas.org/doi/10.1073/pnas.2215799119
#mitochondria #LiveCellimaging #PKmito
Capturing the pathomechanisms of different disease severities in a human cerebral organoid model of LIS1-lissencephaly https://www.biorxiv.org/content/10.1101/2022.12.19.520907v1?med=mas
RT @StevenXGe
Happy holidays! Introducing http://RTutor.ai, an AI-powered app that lets you chat with your data in English! RTutor uses Davinci (#ChatGPT’s sibling) to turn requests into R code, which is executed & results are shown instantly, available as a HTML report in seconds. 1/8
RTutor

Check out also two back-to-back papers that describe homologous systems. One that describes the Bim1/Bik1/Kar9 system in budding yeast, and the mechanism of non-stoichiometric accumulation of Kar9 at a single microtubule end: https://www.nature.com/articles/s41556-022-01035-2

And the other, examining how specific mutations that disrupt in vitro phase separation of EB1 correlate with EB1's effects on microtubule dynamics and mitotic progression: https://www.nature.com/articles/s41556-022-01033-4

Multivalency ensures persistence of a +TIP body at specialized microtubule ends - Nature Cell Biology

Maan et al., Meier et al. and Song et al. report that microtubule plus-end binding proteins can undergo liquid–liquid phase separation to regulate microtubule dynamics.

Nature

Our paper is published today after peer-review: https://www.nature.com/articles/s41556-022-01037-0

We asked whether protein complexes that follow growing microtubule ends are liquid condensates or not. The answer is not a simple yes or no, so give it a read if you are interested. I find these panels particularly informative

Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends - Nature Cell Biology

Maan et al., Meier et al. and Song et al. report that microtubule plus-tip end binding proteins can undergo liquid–liquid phase separation and regulate microtubule dynamics.

Nature

RT @EMBLEvents
Would you like to get some hands-on training on expansion microscopy (ExM)? 🔬 Join this 5-day EMBL Course and you'll be all set to use this powerful technique and apply it in your lab 👩🏾‍🔬 #EMBLExM
📥 Apply by 27 Feb
📅 22–26 May 2023
🗺️ EMBL Heidelberg

🌐 http://s.embl.org/eic23-02

Expansion microscopy

How does #bacterial #RNA #chaperone #Hfq regulate numerous different #mRNAs and processes?
#CryoEM by Tom Dendooven, Ben Luisi and collaborators shows assembly into distinct polymorphic #ribonucleoprotein complexes as basis

Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding

https://www.embopress.org/doi/full/10.15252/embj.2022111129