CRAIG M CREWS

@crews@mstdn.science
983 Followers
1.4K Following
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Yale Professor interested in all things #TargetedProteinDegradation and #biopharma #startups
Lab websitehttp://crewslab.yale.edu
Twitter@CraigMCrews
Interests#ChemicalBiology, academic #drugdevelopment, #TargetedProteinDegradation

Leonard Hayflick (May 20, 1928 – August 1, 2024) , who discovered the cellular replication limit.

The serial cultivation of human diploid cell strains
https://www.sciencedirect.com/science/article/abs/pii/0014482761901926

The serial cultivation of human diploid cell strains

The isolation and characterization of 25 strains of human diploid fibroblasts derived from fetuses are described. Routine tissue culture techniques we…

On this day in 1888: Selman A Waksman was born. He won 1952 #NobelPrize for his discovery of streptomycin #ThisDayInBiotech
Interesting article about the amazing chemical proteomics research at Scripps Research. Chris Parker highlights the groundbreaking work in the field by e.g. Ben Cravatt and John Yates as well as some of the breakthroughs that his own lab has introduced. https://theanalyticalscientist.com/fields-applications/chemical-proteomics-realizing-therapeutic-potential
Chemical Proteomics: Realizing Therapeutic Potential

Chris Parker discusses Scripps’s proteomic legacy and how his work in photoaffinity-based chemical proteomics is leading to the development of potential new therapies

The Analytical Scientist
On this day in 2013: Frank Ruddle died, created 1st transgenic mouse, laid pathway for Human Genome Project http://whatisbiotechnology.org/index.php/people
The Biotechnologists

A collection of information and resources about some of the people whose work has helped build biotechnology into one of the most important tools in our lives.

WhatisBiotechnology.org

As previously mentioned, here's what Einstein had to say about segregation:

"There is a separation of white people and colored people in the United States. That separation is not a disease of colored people. It is a disease of white people. I do not intend to be quiet about it."

For the last 20 years of his career, Einstein declined almost all public speaking engagements, except those at Historically Black Colleges and Universities (HBCUs).

This photo was taken at Lincoln University, an HBCU.

Online Now: Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00093-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Online Now: Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00089-3?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity https://covalentmodifiers.blogspot.com/2024/02/discovery-of-6-formylpyridyl-urea.html?utm_source=dlvr.it&utm_medium=mastodon
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity

Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-min Zhang, ...