π€ Are protein language models the next revolution in functional genomics?
π Fine-tuning protein language models to understand the functional impact of missense variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.022
π CSBJ: https://www.csbj.org/
#Genomics #AI #ProteinLanguageModels #Bioinformatics #PrecisionMedicine #PLM #MissenseVariants #MachineLearning #ClinicalGenetics #AIinHealthcare #InterpretableAI #VariantInterpretation
DECIPHER version 11.29 has been released. See the new features at
https://www.deciphergenomics.org #variantinterpretationDECIPHER v11.29: Mapping the clinical genome
DECIPHER helps the clinical community share and compare human genome variants and phenotypes in a database of tens of thousands of patients worldwide
DECIPHER version 11.27 has been released. See the new features at
https://www.deciphergenomics.org #variantinterpretationDECIPHER v11.29: Mapping the clinical genome
DECIPHER helps the clinical community share and compare human genome variants and phenotypes in a database of tens of thousands of patients worldwide
Cross-protein transfer learning substantially improves zero-shot prediction of disease variant effects
https://doi.org/10.1101/2022.11.15.516532
#disease #variantInterpretation #mutation #transferLearning
CSBJ
deciphergenomics
Francesco Strozzi
Andreas PrliΔ
Andreas Prlic