π Could a protein that twists into filaments reveal how cells keep themselves in balance?
π Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.018
π CSBJ: https://www.csbj.org/
#StructuralBiology #CryoEM #Thorase #MolecularBiology #mTORC1 #ProteinStructure #Biophysics #AAAplusATPase #SynapticPlasticity #Mitochondria
π mTORC1 Research: New Findings Challenge Old Model π§«π§ͺCongrats to the Demetriades Lab team! #mTORC1
#Research
https://www.age.mpg.de/415628/241122_mtor_on_the_move?c=2930
Eating less, intermittent fasting, anti-ageing drugs such as rapamycin - there is a lot of public advice on preventing age-related diseases. A central regulator that appears to be linked to all these measures is a protein complex called mTORC1 that functions in our cells both as a sensor of nutrient availability and as a controller of most cellular functions. A research group at the Max Planck Institute for Biology of Ageing in Cologne has now shown for the first time that mTORC1 functions differently at different locations inside cells. These new findings broaden our understanding of how mTORC1 is activated by nutrients and may help to develop new, more-targeted therapies against ageing and age-associated diseases.
Respiratory virus infections cause millions of hospitalizations worldwide each year. Severe infections lead to lung damage that coincides with persistent inflammation and a lengthy repair period. Vaccination and anti-viral therapy help to mitigate severe infections prior to or during the acute stage of disease, but there are currently limited specific treatment options available to individuals suffering from the long-term sequelae of respiratory viral infection. C57BL/6 mice were infected with influenza A/PR/8/34 as a model for severe viral lung infection and allowed to recover for 21 days.
An exciting article out in @biorxivpreprint shows that AMPK inhibits autophagy during glucose starvation in U2OS cells.
https://www.biorxiv.org/content/10.1101/2023.09.28.559981v2
Whether glucose starvation induces or inhibits autophagy is a controversial topic, something my lab discovered when we struggled for almost two years to publish our findings that in yeast glucose starvation actually actively suppresses autophagy ten years ago.
Interesting π€. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.
A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1
CSBJ
MPI for Biology of Ageing
Giuseppe Michieli
MCDuncanLab
DaveFinlayTCD