An exciting article out in @biorxivpreprint shows that AMPK inhibits autophagy during glucose starvation in U2OS cells.
https://www.biorxiv.org/content/10.1101/2023.09.28.559981v2
Whether glucose starvation induces or inhibits autophagy is a controversial topic, something my lab discovered when we struggled for almost two years to publish our findings that in yeast glucose starvation actually actively suppresses autophagy ten years ago.
In yeast, it now seems quite evident that the low energy status caused by glucose starvation in glycolytic cells causes all sorts of interesting responses, including the inhibition of autophagy as nicely shown by Yoshinori Ohsumi.
https://pubmed.ncbi.nlm.nih.gov/29042435/
In mammalian cells, there are contradicting findings. I wonder whether these differences are explained by different glycolytic versus respiratory profiles of the cell lines used.
Autophagy is a conserved process in which cytoplasmic components are sequestered for degradation in the vacuole/lysosomes in eukaryotic cells. Autophagy is induced under a variety of starvation conditions, such as the depletion of nitrogen, carbon, phosphorus, zinc, and others. However, apart from n …
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