Bluesky

Bluesky

Stress dynamically modulates neuronal autophagy to gate depression onset - Nature

Acute stress activates autophagy in the lateral habenula, whereas chronic stress suppresses it, with this autophagy having a causal role in maintaining emotional homeostasis against stress, and its restoration through autophagy enhancers offers a novel antidepressant strategy.

Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation

Autophagy-related proteins have roles in several cellular processes, but their function in genome stability remains unclear. Here, the authors show that Atg11 has an essential non-canonical function in error-free chromosome segregation via the Kar9-dependent spindle positioning pathway.

Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling

Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells

Caspase enzymes are traditionally known for their roles in late stages of apoptosis, but growing evidence supports their function in non-apoptotic cellular processes. This study shows that caspase-3 and caspase-7 promote cytoprotective autophagy in response to non-lethal stress by modulating PARP1 activity in breast cancer cells.

Cellular clean-up: Solving the mystery of how cells initiate their recycling process

A new discovery from an international collaborative research team has solved the mystery of how cells turn on their recycling process and create "garbage bags" to remove proteins.

Málstofa Lífvísindaseturs - Roles of the autophagy gene ATG7 in health and disease 

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