Interesting π€. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.
A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1
TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers
Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241
The stress-responsive transcription factor TFEB is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. Integrative genomic analyses identify the immediate-early gene EGR1 as a positive transcriptional regulator of TFEB expression and reveal the function of the EGR1-TFEB transcriptional axis in physiology and disease.
The stress-responsive transcription factor TFEB is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. Integrative genomic analyses identify the immediate-early gene EGR1 as a positive transcriptional regulator of TFEB expression and reveal the function of the EGR1-TFEB transcriptional axis in physiology and disease.
The stress-responsive transcription factor TFEB is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. Integrative genomic analyses identify the immediate-early gene EGR1 as a positive transcriptional regulator of TFEB expression and reveal the function of the EGR1-TFEB transcriptional axis in physiology and disease.
The EMBO Journal
DaveFinlayTCD
PLOS Biology