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Pycnogenol (PYC), a standardized extract derived from the bark of the French maritime pine (Pinus pinaster ssp. atlantica), exhibits a broad spectrum of biol...
Is the psychological benefit of nature a universal human trait or just a Western luxury? A sweeping new study of nearly 37,000 people across 75 countries reveals that feeling connected to the natural world improves well-being globally.
Ketamine is a versatile pharmacologic agent whose unique receptor interactions explain its broad applicability in emergency medicine. Its primary mechanism of action is non-competitive antagonism of N-methyl-D-aspartate (NMDA) receptors, which underlies its dissociative, anesthetic, and analgesic pr …
Analysis of nearly 700,000 health records reveals age-related association between cannabis use disorder and subsequent psychiatric disorders diagnoses.
We investigated ketamine's neuroplastic effects in healthy human subjects using integrated Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) measures before and 1-8 days after a single psychedelic dose of ketamine (1 mg/kg, intravenous). Eleven male participants underwent two PET/M …
Psilocybin, <i>N,N</i>-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD), and 3,4-methylenedioxymethamphetamine (MDMA) are psychedelic compounds with therapeutic potential for depression, anxiety, and post-traumatic stress. However, their relevance to endurance athletes, who face particular …
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