JIPBFeb 3, 2025
How do crop #plants protect their reproductive stage from #heat stress?
Ci et al. reveal a conserved mechanism by which ALBA3 safeguards male #fertility under HS conditions by stabilizing specific #mRNAs crucial for #pollen function. https://doi.org/10.1111/jipb.13846
@wileyplantsci
#PlantSci #JIPB #botany
Scientific FrontlineMar 22, 2024
Messenger #RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several #COVID-19 #vaccines. But #mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being developed as a new class of drugs.
#Biotechnology , #Bioengineering #Biology #sflorg
https://www.sflorg.com/2024/03/btec03222401.html
Messenger RNAs with multiple “tails” could lead to more effective therapeutics

Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

PLOS BiologyMar 4, 2024
Watching worm #RNA: @mango_s_lab adapt the MS2-MCP system to visualize endogenous #mRNAs in #Celegans. Inactivating #NMD & expressing low levels of cytoplasmic MCP allows live imaging of functional transcripts in #nematodes @biozentrum #PLOSBiology https://plos.io/3wBaMpA
An adapted MS2-MCP system to visualize endogenous cytoplasmic mRNA with live imaging in Caenorhabditis elegans

This study adapts the MS2-MCP system to visualize endogenous mRNAs in Caenorhabditis elegans. Inactivating nonsense-mediated decay and expressing low levels of cytoplasmic MCP allows the live imaging of functional, cytoplasmic transcripts in the nematode.

Helmholtz Institute WürzburgNov 17, 2023

The World Antimicrobial Resistance Awareness Week (#WAAW) starts tomorrow, but at the #HIRI, the battle against #AntibioticResistance is a year-round task. 🦠 We are searching for new targets in various germs, as conventional antibiotics are becoming increasingly ineffective: https://www.helmholtz-hiri.de/en/newsroom/features-stories/the-silent-pandemic/

One promising solution are programmable antibiotics, ASOs, studied by the laboratory of HIRI Director Jörg Vogel. They target #mRNAs needed by bacteria to synthesize new proteins & replicate. 🧬

The Silent Pandemic

Helmholtz Institute for RNA-based Infection Research
halama_immunoJul 24, 2023
This weekend we had our first #HITRON Strategy Workshop. It was a very successful event with plenty of ideas for #PersonalizedMedicine with #immunology & #mRNAs and we developed awesome new future projects! Great people – great ideas! Take a look https://hi-tron.dkfz.de/ #oncology #translationalmedicine #machinelearning @dkfz @datasciencedkfz @helmholtz @hereon @association @cyrilpedia @science_wallet
halama_immunoJun 26, 2023
Groundbreaking ceremony for the new building of the Helmholtz Institute for Translational Oncology #HI-TRON in Mainz (Germany), providing a space for novel cutting-edge #immunotherapy development, #personalizedmedicines and #mRNAs as tools in #cancer #research @mainz_de @unimainz @helmholtz @hereon @dkfz
https://www.dkfz.de/de/presse/pressemitteilungen/2023/dkfz-pm-23-33a-HI-TRON-Mainz-ein-Helmholtz-Institut-des-DKFZ-erhaelt-neues-Gebaeude.php
halama_immunoMay 12, 2023
Personalized #mRNAs for #pancreaticancer #patients : #neoantigens utilised for mRNA–lipoplex nanoparticle-based #vaccines stimulate #TCells in a clinical #trial. Combination of sequentially administered atezolizumab (anti-PD-L1 i#mmunotherapy), autogene cevumeran (maximum 20 neoantigens / patient) and a modified #chemotherapy regimen (mFOLFIRINOX, comprising folinic acid, fluorouracil, irinotecan and oxaliplatin) leads to improved recurrence free survival. #immunology https://www.nature.com/articles/s41586-023-06063-y
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer - Nature

A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

Nature
CellBioNewsMar 9, 2023

How does #RNA know where to go in the city of the #cell? Using cellular ZIP codes and postal carrier routes.

#regulation #mRNAs

https://phys.org/news/2023-03-rna-city-cell-cellular-codes.html

How does RNA know where to go in the city of the cell? Using cellular ZIP codes and postal carrier routes

Before 2020, when my friends and acquaintances asked me what I study as a molecular biologist, their eyes would inevitably glaze over as soon as I said "RNA." Now, as the COVID-19 pandemic has shown the power and promise of this molecule to the world at large, their eyes widen.

Enrico BucciFeb 24, 2023

ADENOVIRUS VS RNA

Un nuovo studio ha messo a confronto, in assenza di infezioni pregresse, il vaccino di Astra Zeneca con quello di Pfizer.
I dati ottenuti sono interessanti, soprattutto in vista dello sviluppo di futuri prodotti.

#vaccines #adenovirus #mRNAs

https://www.ilfoglio.it/scienza/2023/02/24/news/nuove-verita-e-scoperte-sui-vaccini-contro-il-covid-19-tra-efficacia-ed-effetti-avversi-4989740/amp/

Nuove verità e scoperte sui vaccini contro il Covid-19: tra efficacia ed effetti avversi

Uno studio australiano rivela nuove differenze tra Pfizer, a tecnologia a mRna, e Astrazeneca o J&J che usano un virus innocuo. Dalle rarissi

Show threadIhthishamFeb 19, 2023

MRNA was discovered in the early 1960's, John Hopkins states. Some were used to fight the Ebola virus. Researchers are also currently working to use mRNA to prevent other respiratory viruses.

According to the National Cancer Institute, mRNA vaccines are being studied to treat people with various types of cancer. The research that was done to treat people with cancer before the pandemic struck helped spearhead the COVID vaccine, the NCI says.

#moreyouknow #covid #cancer #vaccines #mRNAs #virus

https://www.ktvb.com/article/news/local/capitol-watch/idaho-lawmakers-introduce-legislation-to-criminalize-those-who-administer-covid-vaccines-legislature/277-2436a514-e7da-4b31-9762-f9be10300075