Fluidics - Wikipedia

Design and validation of a frugal, automated, solid-phase peptide synthesizer

Solid phase peptide synthesis (SPPS) has enabled widespread use of synthetic peptides in applications ranging from pharmaceuticals to materials science. The demand for synthetic peptides has driven recent efforts to produce automated SPPS synthesizers which utilize fluid-handling components common to chemistry laboratories to drive costs down to several thousand dollars. Herein, we describe the design and validation of a more ‘frugal’ SPPS synthesizer that uses inexpensive, consumer-grade fluid-handling components to achieve a prototype price point between US$300 and $600. We demonstrated functionality by preparing and characterizing peptides with a variety of distinct properties including binding functionality, nanoscale self-assembly, and oxidation-induced fluorescence. This system yielded micromoles of peptide at a cost of approximately $1/residue, a cost which may be further reduced by optimization and bulk purchasing.

Projects and Research: Education - Programmable Water

Paulo Blikstein's web site. Visiting Scholar at the MIT Media Lab's Future of Learning Group.

Method to separate microplastics from water could also speed up blood analyses

Researchers have demonstrated a way to speed up—and potentially scale up—the process for separating particles in fluids, which can be used for studying microplastics in drinking water or even analyzing cancer cells from blood.

Versatile fluidic platform for programmable liquid processing

Society relies heavily on diverse fluidic technologies. The ability to precisely capture and release various chemical and biological fluids plays a fundamental role in many fields. A long-standing challenge is to design a platform that enables the switchable capture and release of liquids with precise spatial and temporal control and accurate volumes of the fluid.

An open source toolkit for 3D printed fluidics - Journal of Flow Chemistry

As 3D printing technologies become more accessible, chemists are beginning to design and develop their own bespoke printable devices particularly applied to the field of flow chemistry. Designing functional flow components can often be a lengthy and laborious process requiring complex 3D modelling and multiple design iterations. In this work, we present an easy to follow design workflow for minimising the complexity of this design optimization process. The workflow follows the development of a 3D printable ‘toolkit’ of common fittings and connectors required for constructing basic flow chemistry configurations. The toolkit components consist of male threaded nuts, junction connectors and a Luer adapter. The files have themselves been made freely available and open source. The low cost associated with the toolkit may encourage educators to incorporate flow chemistry practical work into their syllabus such that students may be introduced to the principles of flow chemistry earlier on in their education and furthermore, may develop an early appreciation of the benefits of 3D printing in scientific research. In addition to the printable toolkit, the use of the 3D modelling platform – Rhino3D has been demonstrated for its application in fluidic reactor chip design modification. The simple user interface of the programme reduces the complexity and workload involved in printable fluidic reactor design.