Il corpo umano nasconde la sua versione personale di Ozempic: una molecola di soli 12 aminoacidi chiamata BRP. I ricercatori Stanford l'hanno isolata tra 20.000 geni e funziona esclusivamente sul cervello, dimezzando l'appetito senza effetti collaterali. Nei test animali? Perdita di peso senza nausea o complicazioni. Niente farmaci sintetici: la prossima svolta anti-obesità è già dentro di noi.
#Ozempic #Dimagrimento #Peptide #Stanford #Obesità
https://www.futuroprossimo.it/2025/03/stanford-svela-un-ozempic-naturale-senza-effetti-collaterali/
Design and validation of a #frugal, #automated, #OpenSource solid-phase #peptide #synthesizer (#SPPS):
-#Raspi/#Python-controlled
-hardware cost: US $300 to $600
-yield: µmoles of peptide at a cost of ~$1/residue
https://doi.org/10.1371/journal.pone.0237473
#DIYbio #lab #instruments #chemistry #fluidics
Solid phase peptide synthesis (SPPS) has enabled widespread use of synthetic peptides in applications ranging from pharmaceuticals to materials science. The demand for synthetic peptides has driven recent efforts to produce automated SPPS synthesizers which utilize fluid-handling components common to chemistry laboratories to drive costs down to several thousand dollars. Herein, we describe the design and validation of a more ‘frugal’ SPPS synthesizer that uses inexpensive, consumer-grade fluid-handling components to achieve a prototype price point between US$300 and $600. We demonstrated functionality by preparing and characterizing peptides with a variety of distinct properties including binding functionality, nanoscale self-assembly, and oxidation-induced fluorescence. This system yielded micromoles of peptide at a cost of approximately $1/residue, a cost which may be further reduced by optimization and bulk purchasing.
#AI model generates #antimicrobial #peptide structures for screening against treatment-resistant microbes
https://phys.org/news/2025-02-ai-generates-antimicrobial-peptide-screening.html
A team of microbiologists, chemists and pharmaceutical specialists at Shandong University, Guangzhou Medical University, Second Military Medical University and Qingdao University, all in China, has developed an AI model that generates antimicrobial peptide structures for screening against treatment-resistant microbes.
Mutation-Tolerant
SARS-CoV-2 Inhibitor Peptide
February 08, 2025 • (S3 E3 )
CESPES isn't just a potential COVID treatment. It's a blueprint for a more sophisticated approach to understanding complex systems.
EPISODE LINKS
buzzSprout
https://www.buzzsprout.com/2405788/episodes/16575779
substack
https://open.substack.com/pub/helioxpodcast/p/mutation-tolerant-sars-cov-2-inhibitor
Heliox Podcast
( please subscribe, follow, like ". )
https://episodes.fm/1769969487
https://www.patreon.com/c/HelioxPodcast
Imagine a scientific approach that doesn't just chase mutations but finds the bedrock beneath the chaos. This isn't science fiction. This is happening right now in a laboratory studying COVID-19, and it could transform how we understand everything...
Eine nachhaltige #Recyclingmethode für Palladium-haltige Katalysatoren gibt es bislang nicht. Angela Thewes und Dr. Nora Schönberger vom #HZDR wollen das ändern. Mit #Pep2Rec entwickeln sie ein biologisches Trennverfahren, das auf #Peptide mit besonderen Eigenschaften setzt.
In der Chemie- und Pharmaindustrie kommt Palladium als wichtiger Katalysator zum Einsatz. Der Herausforderung, Palladium-haltige Katalysatoren zu recyceln, stellt sich nun die neue Nachwuchsforschungsgruppe Pep2Rec am Helmholtz-Institut Freiberg für Ressourcentechnologie des Helmholtz-Zentrums Dresden-Rossendorf. Geleitet von Dr. Nora Schönberger entwickelt die Gruppe ein auf Peptide gestütztes, vollständig biologisches Trennsystem. Das BMBF unterstützt Pep2Rec in der Initiative „BioKreativ“ mit einer Fördersumme von rund 2,75 Millionen Euro.
The two #systemin #peptide #receptors in tomatoes have opposite functions. While SYR1 activates systemin-induced #immune responses, SYR2 acts as an antagonist. Wounding preferentially induces the expression of SYR2 that attenuates immune responses by outcompeting SYR1 for binding with the co-receptor SERK3a
https://www.cell.com/action/showPdf?pii=S1534-5807%2824%2900670-1
Very interesting study using #arabidopsis showing commensal #rhizobacteria secrete a subtilase that suppresses plant #immunity by cleaving #peptide elicitors
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01414-1
halama_immuno
Futuro Prossimo 
Bose-Einstein-Kondensat
CellBioNews
Zoomers of the Sunshine Coast
Polypeptide.org
HZDR
Elly Poretsky
BAM Materialforschung