Nevada Regulators Fine Peptide Providers at Anti-Aging Festival Where Two Women Became Critically Ill
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Three individuals, along with the group accused of supplying the peptides, were fined between $5,000 and $10,000 for their involvement in an incident at the Revolution Against Aging and Death Festival in Las Vegas last summer.
https://www.propublica.org/article/raadfest-peptide-injections-nevada-fines?utm_source=mastodon&utm_medium=social&utm_campaign=mastodon-post

#News #Nevada #LasVegas #Health #Medicine #Doctors #Peptide

Now in Chem Sci! 🎉
We investigated how #enzymes in the #nonribosomal #biosynthesis of life-saving #peptide #antibiotics can be engineered.
Assuming that #promiscuity serves as a springboard for #evolution, we measured the specificity profiles of hundreds of mutants. The results revealed remarkable shifts in substrate specificity in multiple directions, highlighting the evolutionary potential of these enzymes and leading the way for engineering antibiotic biosynthesis.

https://doi.org/10.1039/D6SC00250A

How can we improve peptide- and protein-based drugs and equip them with new functions?

In #Lunteren2026, Jeffrey Bode talked about the synthesis of challenging, chemically modified proteins using a combination of solid-phase peptide synthesis, recombinant expression and ligation strategies like the KAHA ligation.
https://pubs.acs.org/doi/abs/10.1021/acs.accounts.7b00277

He also talked about the synthesis of defined ubiquitin multimers using a chemoenzymatic strategy.
https://chemrxiv.org/doi/10.26434/chemrxiv-2025-943j7

#Chemistry #Peptide #DrugDiscovery

How can peptide-based drugs be modified at a late stage for further biological evaluation?

At #Lunteren2026, Eva Meeus told us about her amazing work on modifying the skeleton of tryptophan in peptides through nitrogen atom insertion.

https://pubs.acs.org/doi/abs/10.1021/jacs.5c16498
#Chemistry #ChemBio #Peptide

How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.

https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01084
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01599

#DrugDiscovery #Peptide #Macrocycle #Cholesterol #PCSK9

Peptide sind in den USA im Mainstream angekommen. Es geht sogar soweit, dass die Mitarbeiter:innen sie per Spritze bei einem Gesundheits-Tech-Startup in Los Angeles freitags kostenlos bekommen können. 🥴 (€)

#Gesundheit #Peptide

https://t3n.de/news/verrueckt-geworden-welle-peptide-1731955/

Dieser Artikel hat besonders viele Abonnent:innen interessiert. (+)

#Peptide #Gesundheit #Sport

https://t3n.de/news/vom-muskelaufbau-bis-zur-ausgabe-in-us-tech-startups-was-hinter-dem-peptide-trend-steckt-1731955/