Big Fl👀f is watching you.
katch wreck`We find that combining RNA-seq perturbation-based networks with VIPER (Virtual Inference of Protein Activity by Enriched Regulon analysis) accurately captures splicing factor activity as modulated by multiple regulatory layers. This approach integrates splicing factor regulation into a single score derived solely from exon inclusion signatures, allowing functional interpretation of heterogeneous conditions.`
PLOS BiologyWhat is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @PLOSBiology https://plos.io/3Pcs2e6
Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans
Alternative transcription initiation, splicing and polyadenylation generate extensive transcript diversity in eukaryotes, but its evolutionary significance has been disputed. This study analyses 166 transcriptomes across 75 metazoan species to show that transcript diversity generally decreases with effective population size, supporting the view that most transcript diversity reflects deleterious RNA processing errors rather than adaptive functions.
GDCh Division of BiochemistryXinlai Cheng gave an interesting talk at #Biochemistry2026. He talked about his group's research into "Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation".
https://onlinelibrary.wiley.com/doi/10.1002/anie.202516809
#Splicing #Biochemistry #Chemistry #ChemBio
CC: @gdch
Paul SomeoneElseI like this definitions of quasiquote and unquote and unquote-splicing:
https://www.scheme.com/tspl4/objects.html#./objects:h0
I referenced that, but I am looking at it in my paper book, and
the web page looks better because the backtick is more obvious in
my browser. The backtick in my paper book looks the same as
a normal single quote.
But that's not really a problem if anything maybe it makes
me dwell on it longer.
#scheme #quasiquote #unquote #splicing
https://www.scheme.com/tspl4/objects.html#./objects:h0
I referenced that, but I am looking at it in my paper book, and
the web page looks better because the backtick is more obvious in
my browser. The backtick in my paper book looks the same as
a normal single quote.
But that's not really a problem if anything maybe it makes
me dwell on it longer.
#scheme #quasiquote #unquote #splicing
T_XAll parts for the first self-made #fiber line for our "housing" project have been ordered, we can hopefully start with the installation on Tuesday.
If those cold "splicing" quickconnect/fastconnect connectors don't work, does anyone know someone in #Lübeck or #Hamburg who could lend a fiber #splicing device?
If those cold "splicing" quickconnect/fastconnect connectors don't work, does anyone know someone in #Lübeck or #Hamburg who could lend a fiber #splicing device?
Planetární ekologAlternativní splicing (Genetika 🧬)
Alternativní splicing je jev, při němž při transkripci vzniká z jednoho genu více variant mRNA potenciálně kódujících rozdílné bílkovinné produkty. Po přepisu DNA v jádře prochází tzv. primární transkript RNA úpravami, v jejichž rámci se dlouhé nekódující úseky vystřihují a ostatní sekvence je možné spojit různými způsoby. Z výsledných několika RNA vytvořených od...
Sustainable Sailing
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JIPBAlternative #splicing is a crucial post-transcriptional mechanism in #plants. In a new #JIPB review, Zhu et al. explore the potential of AS to provide new strategies for #crop improvement and #sustainable #agriculture.
https://doi.org/10.1111/jipb.13951
@wileyplantsci
#PlantSci #pesticides #botany
https://doi.org/10.1111/jipb.13951
@wileyplantsci
#PlantSci #pesticides #botany
