What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @PLOSBiology plos.io/3Pcs2e6

How do select pre-#mRNAs escape 3’ end-processing inhibition by #DNAdamage?
Stephan Vagner and colleagues (Institut Curie) invoke rescue by a #cotranscriptional cleavage that allows subsequent #posttranscriptional #polyadenylation site processing in the nucleoplasm

Now published, previously a #RefereedPreprint via @ReviewCommons

https://www.embopress.org/doi/10.15252/embj.2022112358

Hi, #genomic and #bioinformatics community! What would you recommend as a good list of poly-adenylation signals in yeast (ideally with frequency or predictive power information)? #polyAdenylation #yeast