U01.01.100 Pyruvate Metabolism: The Four Fates of Pyruvate High-Yield Review

Master the metabolic crossroads of Pyruvate with our U01.01.100 guide. Learn the four major fates of pyruvate: conversion to Acetyl-CoA, Oxaloacetate, Lactate, and Alanine. Understand the enzymes, cofactors, and clinical significance of each pathway for USMLE Step 1. Available on mymedschool.org.

mymedschool.org

`Pyruvic acid (IUPAC name: 2-oxopropanoic acid, also called acetoic acid) (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. #Pyruvate, the conjugate base, CH3COCOO−, is an intermediate in several #metabolic pathways throughout the #cell.`

https://en.wikipedia.org/wiki/Pyruvic_acid

#respiration #glycolysis #oxidation #redox #combustion #redoxChemistry #biochemistry #biochem #chemistry

Pyruvic acid - Wikipedia

"Furthermore, genetic Mpc1 ablation in vitro and in vivo also activates neural stem/progenitor cells (NSPCs), which differentiate into mature neurons, leading to overall increased hippocampal neurogenesis in adult and aged mice. These findings highlight the importance of metabolism for NSPC regulation and identify an important pathway through which mitochondrial pyruvate import controls NSPC quiescence and activation."
https://www.science.org/doi/10.1126/sciadv.add5220#:~:text=Furthermore%2C%20genetic%20Mpc1,quiescence%20and%20activation.

#neurogenesis #stemCells #mitochondria #pyruvate