New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to #immunotherapy is observed. These findings are then put into action for patient stratification, showing the utility in #radiology and #medicaloncology and #oncology #Science #medicine #immunology

https://www.nature.com/articles/s41392-026-02594-8

A new Collection on #cancer is out @PLOSBiology! We delve into how #omics technologies are helping researchers understand the #tumor #microenvironment (TME)

Edited by Yibin Kang, who wrote a great Editorial to frame the Collection, this group of Essays and Perspectives covers topics as diverse as:

- mutual plasticity of #cancer & immune cells in the #TME & why its relevance in therapy
- metabolic crosstalk between cancer and T cells, and how to leverage it to reprogram anti-tumor immune responses
- the potential of defining the 3D tumor neural niche using spatial omics & #AI technologies to identify new targeted therapy opportunities
- evolutionary selection operating across levels in cancer, highlighting how this understanding can be used to improve prevention and treatment
- mathematical models as tools for exploring the complex interplay between #cancer cells and their environment, and the role of AI in leading the way towards the next wave of tumor models
- how #MultiOmics data be leveraged to help cancer patients
- how single-cell technologies can help understand cancer metastatic niches and inform novel therapies
- a call for better preclinical models and improved understanding of stromal cell function in the TME

Senior cancer editor @PLOSBiology, Richard Hodge, discusses his vision for cancer biology at the journal in an accompanying Biologue post.

Take a look at let us know what you think!

https://plos.io/4mgHDEw

New #mechanobiology paper on #cancer #microenvironment. The authors show that cancer-associated #fibroblasts (CAFs) compress tumors with actomyosin supracellular contractility supported by #fibronectin deposition. This induces #YAP nuclear exit in cancer cells, limits cancer growth, and induces tumor reorganization.

https://www.nature.com/articles/s41467-023-42382-4

Come and work with us - job opening at the Molenaar research group in the Princess Máxima Center for pediatric oncology, looking for a #bioinformatician / #DataScientist.

Together with my colleagues and me you will research #neuroblastoma, with a focus on #tumour #microenvironment and the #immune compartment using a range of #sequencing data and other high-throughput data.

#CancerResearch #scRNAseq
#FediJobs #JobOffer

For further information, see the vacancy below:
https://werkenbijprinsesmaximacentrum.nl/en/vacancy/bioinformatics-research-scientist/