“This #preprint has provided me with a fresh outlook on the significance of the extracellular matrix in tissue morphogenesis and organ development.”
First preLights post by Bhaval Parmar covering work from Cecília G. De Magalhães & team
#preLight 👉 https://prelights.biologists.com/highlights/lens-placode-modulates-extracellular-matrix-formation-during-early-eye-development-v2/
New #mechanobiology paper on #cancer #microenvironment. The authors show that cancer-associated #fibroblasts (CAFs) compress tumors with actomyosin supracellular contractility supported by #fibronectin deposition. This induces #YAP nuclear exit in cancer cells, limits cancer growth, and induces tumor reorganization.
Cancer-associated fibroblasts (CAFs) can produce ECM and form a physical barrier around the tumour. Here, the authors show in transgenic mouse models and in vitro systems that CAFs are able to actively compress cancer cells using actomyosin contractility and this leads to a modulation of cancer cell mechanosensing and tumour reorganisation.
@CortJohnson
on
@BhupeshPrusty
#MEcfs #Sleepless #fibronectin #dUTPases #MessedUpMitochondria
Matt Willemsen
preLights
Julien Delpierre
BenNevis