Mastodawn

How does nutrient deficiency in the #tumor #microenvironment lead to metabolic reprogramming? This study reveals a mechanism for glioblastoma survival via switching from #glycolysis to #FattyAcid oxidation in mice, with implications for cancer medicine @PLOSBiology https://plos.io/3P6pSg4

USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice

We discover a novel function of PFKM in promoting glioma cell survival under glucose deficiency by switching metabolism from glycolysis to FAO. Upon GD, the levels of F-2,6-BP are decreased, leading to the enhanced interaction between USP7 and PFKM. USP7 then deubiquitinates PFKM K615 and promotes its nuclear translocation. Nuclear PFKM enhances c-Myc-dependent expression of CPT1B and the activity of FAO, and promotes tumor cell survival under GD.

Alexander J. Stein Jul 29, 2025

Meat & #dairy substitutes gain popularity. Using #plantbased substitutes—with reduced consumption of red & processed #meat, increased #fiber & improved #fattyacid intake—would be the most effective in reducing premature deaths from #cancer & cardiometabolic diseases… (1/2) doi.org/10.1016/j.aj...

Redirecting

The FSBI May 22, 2025

#Eels can complete their growing phase in either marine or freshwater environments. Their essential #fattyacid composition is likely defined by food intake and environment but correlations between FA biosynthesis genes suggested that genetics may also play a role: doi.org/10.1111/jfb.16052 #JFB

http://doi.org/10.1111/jfb.16052

PLOS Biology Apr 30, 2025

#Chlamydia cause millions of infections annually, but their obligate intracellular lifestyle makes treatment difficult. This study develops a platform that identified >60 new #antichlamydial compounds, including one that inhibits bacterial #FattyAcid synthesis @PLOSBiology https://plos.io/4jycCuT

A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia

Bacteria of the genus Chlamydia cause millions of infections each year and have an obligate intracellular lifestyle that makes finding specific treatments particularly difficult. This study developed a discovery platform that identified over sixty new potent antichlamydial compounds, including one that selectively inhibits bacterial fatty acid synthesis.

PLOS Biology Apr 29, 2024

Yeast mitofusin Fzo1 localizes to #peroxisomes to promote tethering with #mitochondria. This study shows that these Fzo1-mediated PerMit contacts are required to maintain mitochondrial fusion as #FattyAcid desaturation increases @lbmce_umr8226 @PLOSBiology https://plos.io/3UhoKFi

Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion

The yeast mitofusin Fzo1 naturally localizes to peroxisomes to promote their tethering with mitochondria, but the physiological relevance of this contact is unclear. Here, the authors show that these Fzo1-mediated PerMit contacts are required to maintain mitochondrial fusion as fatty acid desaturation increases.

Steve Dustcircle 🌹May 2, 2023

Curbing #fattyacid production in #bacteria lowers #antibiotic resistance
https://www.newscientist.com/article/2371406-curbing-fatty-acid-production-in-bacteria-lowers-antibiotic-resistance/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=news

Curbing fatty acid production in bacteria lowers antibiotic resistance

Bacteria are more susceptible to antibiotics when they can't produce fatty acids, suggesting that drugs inhibiting this process could help us overcome antibiotic resistance

New Scientist

The EMBO Journal Mar 20, 2023

Mitochondrial morphology controls #fattyacid utilization by changing CPT1 sensitivity to #malonyl-#CoA

Orian Shirihai, Nika Danial and coworkers show that #mitochondrial fragmentation increases beta-oxidation and cellular #lipid #metabolism via de-repressing #CPT1
https://www.embopress.org/doi/10.15252/embj.2022111901

Hao Yin Dec 12, 2022

#Sirt6 control of #EndothelialCell #FattyAcid transport links #Diabetes microvascular dysfunction with #HeartFailurewithPreservedEjectionFraction #HFpEF

EC Sirt6->
⏬H3K9ac PPARγ promoter
⏬CD36,FABP4/5
⏬🐭 Heart Lipid

Dr. Zheng Gen Jin lab Circ Res 2022
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318988

SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes

Background: Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes is a strong risk factor for

Circulation Research