New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to #immunotherapy is observed. These findings are then put into action for patient stratification, showing the utility in #radiology and #medicaloncology and #oncology #Science #medicine #immunology
Learn about phagocyte dysfunction immunodeficiencies, including CGD, LAD, and Chediak-Higashi syndrome, their mechanisms, and clinical relevance. #Immunodeficiency #PhagocyteDysfunction #CGD #LAD #ChediakHigashi #Immunology #MedicalEducation #USMLE #Pathology #InnateImmunity #NeutrophilDefects
Learn how to identify Leukocyte Adhesion Deficiency Type 1 (LAD-1) on USMLE-style questions. Understand the hallmark features — delayed cord separation, recurrent bacterial infections without pus, and CD18 deficiency — with diagnostic reasoning and high-yield immunology insights.
The Tiny Warriors of Your Immune System: How Our Body Fights Infections
#ImmuneSystem #VaccineScience #SpikeProteins #Antibodies #InnateImmunity #AdaptiveImmunity #StressAndHealth #CytokineStorm #GutHealth #MentalHealthAndImmunity #HealthAwareness #ImmunityBoost #WellnessTips #MedicalScience #StayHealthy
Innate immune signaling acts as a surveillance system to fight potential infections, but it can become overactivated in malignant cells. These authors show that the tissue-protective functions of innate immune signaling involving oncogenic Ras can be misused by premalignant cells in Drosophila to induce overgrowth in the initial stages of tumor development.
New study! Learning about inflammation by studying the differences between mammals – a toot-orial.
https://doi.org/10.1186/s10020-024-01052-x
When the body meets an infectious microbe or similar challenge it activates an inflammatory cascade. Inflammation helps eliminate the microbe, but, if it gets of control, it can be dangerous or even fatal.
We like to assume that inflammation is basically the same for all animals. And this is usually true in cell culture, but in vivo …
1/
Vertebrates differ over 100,000-fold in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhanced expression of LPS-responsive genes relative to resilient species. After LPS stimulation, maximally different genes in resilient species included genes that detoxify LPS, diminish bacterial growth, discriminate sepsis from SIRS, and play roles in autophagy and apoptosis. The findings reveal the molecular landscape of species differences in inflammation. This may inform better selection of species for pre-clinical models and could lead to new therapeutic strategies that mimic mechanisms in inflammation-resilient species to limit inflammation without causing immunosuppression.
halama_immuno
mymedschool
CITO Greenhouse
PLOS Biology
David Gregory
Thiago Carvalho