Lithium chloride shows effects beyond its main target by altering multiple cellular pathways involved in Tau phosphorylation, kinase activity, and Rho GTPase signaling, with implications for Alzheimer’s disease mechanisms. The study maps how lithium interacts with Tau, kinases, and other pathways across cell models, highlighting potential avenues for safer, more effective treatments.

The article is of interest to psychology-oriented readers because it explores cellular mechanisms linked to memory and cognitive decline, offering a biological perspective on factors that influence behavior and mental processes in aging and dementia.

Article Title: Unlocking lithium’s hidden effects on Alzheimer’s disease at the cellular level

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/unlocking-lithiums-hidden-effects-on-alzheimers-disease-at-the-cellular-level/

#Lithium #Alzheimers #Tau #GSK-3β #phosphorylation #RhoGTPases #kinases #neurodegeneration #cellularmechanisms #biomedicine

A true tour-de-force study by the group of Bernhard Küster posted as bioRxiv preprint. They profiled 133 kinase inhibitors in 5 cell lines at 11 doses using #phosphoproteomics with #decryptM to identify 5,318 confident kinase::substrate relationships for 96 human #kinases. https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1

#Chemistry #ChemBio #Proteomics #DrugDiscovery #Signalling