Federal authorities served a search warrant on Wednesday at a Southern California aerospace facility where a chemical tank overheated last month, forcing 50,000 residents to evacuate. The warrant signed by a federal judge last week approved the seizure of documents and records related to the βstorage, use, or disposalβ of methyl methacrylate, the chemical inside the affected tank. The FBI confirmed its agents were searching GKN Aerospace Transparency Systems in the Orange County city of Garden Grove.
PROTACs rely mainly on ubiquitous E3 ligases, limiting tissue selectivity. Here, the authors identify a ligand of muscle specific E3 ligase KLHL41 and develop a covalent PROTAC (cKBD-1) that enables potent, muscle-specific protein degradation in vitro and in vivo.
Nessa Carson
Chemjobber
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Stephan Hacker