GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

I was very happy to be able to talk about some of our work at #Biochemistry2026. I presented results of Patrick Zanon, Marnix Roseboom, Julia Pols and Storm van der Voort on new covalently reactive groups, chemical proteomics methods and screening technologies.

https://www.nature.com/articles/s41557-025-01902-z
#Chemistry #ChemBio #Biochemistry #Chemoproteomics #CovalentInhibitors

Let's start the year off right with an exciting paper post!

In this Chemical Communications paper, the groups of Megan Wright and Stuart Warriner investigate the metal-independent labeling of proteins using isocyanides.

https://pubs.rsc.org/en/content/articlelanding/2026/cc/d5cc04136h
#ChemBio #Chemistry #CovalentInhibitors