We are excited that Matt Bogyo from Stanford will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.
If you do not want to miss anything, follow us and sign up for our mailing list: https://www.universiteitleiden.nl/en/science/led3/abpp2027
How can we develop new antibiotics against the most devastating infections with antibiotic-resistant Gram-negative bacteria?
Thomas Clairfeuille gave an inspiring lecture on this topic in his @LED3hub Lecture, in which he described the discovery and development of the antibiotic zosurabalpin against carbapenem-resistant Acinetobacter baumannii (CRAB). (1/7)
We are very happy that Thomas Clairfeuille from Roche visited us today for a very well attended LED3 Lecture. He talked about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".
https://www.nature.com/articles/s41586-023-06873-0
#Antibiotics #DrugDiscovery #ChemBio #Chemistry
How can virtual screening be combined with in-house synthesis to quickly evaluate hits?
Sean McKenna from our @LED3hub talked about his exciting work on COMBINAUT that allows automated synthesis and purification.
https://chemrxiv.org/doi/full/10.26434/chemrxiv.15000200/v1
#Chemistry #ChemBio #DrugDiscovery
Predicting the stereochemical outcome of glycosylation reactions is a complex problem.
In his talk at #Lunteren2026, Daan Hoogers from the group of Jeroen Codee of our @LED3hub presented his research into the systematic exploration of this question with various methods.
https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc07201h
#Chemistry #ChemBio #Glycotime
Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)
#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL
We urgently need new antibiotics against the most devastating Gram-negative infections. Nevertheless, bringing new classes of antibiotics against them to the clinics has been a huge challenge.
I am very happy that Thomas Clairfeuille from Roche will visit us for a @LED3hub Lecture on March 26th to talk about one of the recent success stories in the field: Zosurabalpin, which targets the LPS transport. (1/2)
We are looking forward to the LED3 Lecture by Thomas Clairfeuille from the Roche Innovation Center on March 26th. He will talk about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
RE: https://mstdn.science/@LED3hub/116160224869791384
It was great to be part of the discussion about the faculty priority themes of our Faculty of Science and to represent the @LED3hub alongside Mario van der Stelt, Laura Heitman and Kim Bonger.
Our theme leader, Mario van der Stelt, introduces our LED3 hub at the meeting of all of our faculty priority themes of our Science Faculty. Great discussions on the annual and communication plan as well as the outlook for the future. Many exciting things are ahead.
ABPP2027
Stephan Hacker