Benjamin Carr, Ph.D. 👨🏻‍💻🧬7h ago
Some #snakes lack the ‘#hunger #hormone.’ Experts are hungry to know why
The #gene for #ghrelin is missing in serpents, yet present in other fasting #reptiles
Evolutionary #geneticist Rui Pinto and colleagues stumbled on the discovery when comparing the #genomes of 112 reptile species, including snakes, crocodiles and chameleons, which they obtained from public database. Genes for ghrelin and its activating enzyme were absent in 32 snake species.
https://www.sciencenews.org/article/snakes-lack-hunger-hormone-ghrelin
https://archive.ph/WvOHr
Some snakes lack the ‘hunger hormone.’ Experts are hungry to know why

The complex biology of ghrelin, the hunger hormone, has researchers wondering how its absence helps snakes last a long time with no food, if at all.

Science News
Komplementer OktatóközpontJan 15
🍩 Súlyszabályozás – A beled kívánja a cukrot, nem te! A baktériumok harca a cukorért! ⚖️
👉 Különösen fontos: A diszbiózis hatására a káros baktériumok erősebben vágynak a cukorra, és ezt az üzenetet közvetítik az agynak!
Üzenet: A diéta és a testsúly elleni küzdelem nemcsak az akaraterődön múlik, hanem azon is, hogy melyik baktériumot eteted!
#elhízás #ghrelin #leptin #cravings #diéta
#aradiágnes #komplementeroktatóközpont #természetgyógyászoktatás #természetgyógyászat #egészség
Show threadRhyothemisApr 30, 2023

@spamless @Medscape

Unfortunately they are yrs away from human trials.

One way to increase ghrelin levels is by drinking carbonated beverages (article title says 'male rats' but they also tested male humans; would be nice to know if true for females) -
https://doi.org/10.1016/j.orcp.2017.02.001

My daughter hates carbonated beverages, tho. I suspect this may have be due to elevated salivary carbonic anhydrase activity.

#ghrelin

Daniela M. PfabiganApr 13, 2023

... and here is the published version of our paper on ghrelin concentrations and social reward - thanks again to my amazing co-authors!! @UtaSailer

More than 60 volunteers, > 120 #fMRI measurements, and > 300 #ghrelin blood samples later...
https://doi.org/10.3389/fpsyt.2023.1104305

In addition to our #preregistration, we ran an exploratory analysis:
... ventromedial prefrontal (#vmPFC) cortical activation to #nonsocial #rewards was reduced when the meal strongly suppressed #ghrelin

Hungry for compliments? Ghrelin is not associated with neural responses to social rewards or their pleasantness

The stomach-derived hormone ghrelin motivates food search and stimulates food consumption, with highest plasma concentrations before a meal and lowest shortly after. However, ghrelin also appears to affect the value of non-food rewards such as interaction with rat conspecifics, and monetary rewards in humans. The present pre-registered study investigated how nutritional state and ghrelin concentrations are related to the subjective and neural responses to social and non-social rewards. In a cross-over feed-and-fast design, 67 healthy volunteers (20 women) underwent functional magnetic resonance imaging (fMRI) in a hungry state and after a meal with repeated plasma ghrelin measurements. In task 1, participants received social rewards in the form of approving expert feedback, or non-social computer reward. In task 2, participants rated the pleasantness of compliments and neutral statements. Nutritional state and ghrelin concentrations did not affect the response to social reward in task 1. In contrast, ventromedial prefrontal cortical activation to non-social rewards was reduced when the meal strongly suppressed ghrelin. In task 2, fasting increased activation in the right ventral striatum during all statements, but ghrelin concentrations were neither associated with brain activation nor with experienced pleasantness. Complementary Bayesian analyses provided moderate evidence for a lack of correlation between ghrelin concentrations and behavioral and neural responses to soci...

Frontiers
Poetry NewsMar 18, 2023

Heart failure struggles,
Hunger hormone may improve -
Hopes of better life

#ghrelin #heartfailure #health #haiku #poetry

http://www.medicalnewstoday.com/articles/could-the-hunger-hormone-help-improve-heart-function-in-people-with-heart-failure

Could the hunger hormone help improve heart function in people with heart failure?

Researchers have found that an activated form of the hunger hormone ghrelin can help people with heart failure by increasing the heart’s pump capacity.

Medical News Today
Show threadRhyothemisFeb 9, 2023

@beth_morton

I came across something interesting on carbonated beverages & ghrelin. Ghrelin was found to reduce pain in a migraine model (1). Drinking carbonated beverages increases ghrelin levels after a meal (2). So my preference for soda rather than tea as a caffeine source during migraine might have something to do with this (as opposed just to being cold, which is also helpful).

1- https://doi.org/10.1093/brain/awp265

2- https://doi.org/10.1016/j.orcp.2017.02.001

#ghrelin #migraine

Cerebellar agenesis revisited

Abstract. New clinical and employment information, together with over-looked previously published information, on a patient (H.C.) is reviewed. H.C., who died a

OUP Academic
Nicola RomanòDec 31, 2022

Happy to share our new article, which has been in the making for a veeery long time!

https://insight.jci.org/articles/view/165763

In this study we looked at the control of the entrance of #ghrelin in the #brain

Ghrelin is a #hormone produced by the stomach, which induces hunger. In order to do so, ghrelin needs to enter the brain, to reach neurons in the arcuate nucleus of the #hypothalamus, a region of the brain important for many #endocrine responses.

Here, we explore the role of cells lining the capillaries (such as #perycytes ) at the median eminence, which is on of the "doors" of the brain, where molecules from the periphery are allowed to get in.

We used a mouse model where pericytes can be electrically excited via #optogenetics to study the dynamics of ghrelin entrance in the brain. When we excited pericytes, there was a slow-down of blood flow at the median eminence, resulting in slower entrance of ghrelin, lower and delayed food intake in response to ghrelin injection.

This shows pericytes as a potential therapeutical target for metabolic diseases.

JCI Insight - Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain

LaborjournalDec 14, 2022

Warum man umso mehr Nadeln in die Voodoo-Puppe seines Partners oder seiner Partnerin sticht, je größer der #Hunger ist – und warum #Ghrelin uns zum #Gremlin macht …

Henrik Müller erklärt uns die "Psycho-Neuro-Physio-#Biochemie des Hungers": 👉 https://www.laborjournal.de/blog/?p=12742

Zur Psycho-Neuro-Physiobiochemie des Hungers « Laborjournal Blog

Corinna SchulzDec 2, 2022
Can gastrointestinal hormones modulate our reward responses? @cecivez and I ventured into the available data and literature to find that
🎯 ghrelin enhances reward responses within the motivational circuit! w/ @nbkroemer

Find more in our pre-print: https://www.biorxiv.org/content/10.1101/2022.11.30.518539v1

#gutbrainaxis #reward #fMRI #ghrelin #GLP1
Corinna SchulzNov 24, 2022

#introduction

I am enjoying reading lots of different introductions over the last days so I will hop on the train as well and introduce myself! 👋

I am a PhD student at the #neuroscience for motivation, action, and desire lab working with @nbkroemer 🧠

I am broadly interested in #decisionmaking and in my PhD I am incorporating a metabolic perspective to understand how the #gutbrainaxis influences neural communication, motivation and effort. 🏋️‍♂️

Many psychiatric disorders come along with both motivational and metabolic alterations so the gut-brain perspective might help us to better understand and treat disorders like #depression #anhedonia 🎯

Mostly here for all the diverse science 💡🤩

#fmri #cognitiveneuroscience #dopamine #ghrelin