Mastodawn

Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions

📰 Original title: Light-guided evolution creates proteins that can switch, sense, and compute

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

View full AI summary: https://killbait.com/en/researchers-develop-light-controlled-protein-evolution-for-dynamic-cellular-functions/?redirpost=71441d18-9f49-49b4-831d-11648d343df8

#science #proteins #optogenetics #evolution

Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions

Scientists at the Ecole Polytechnique Fédérale de Lausanne have developed a novel method called ‘optovolution’ that uses light to guide the evolution of proteins with dynamic behaviors.

KillBait Archive

The vOICe vision BCI 🧠🇪🇺Dec 29

Evaluation of lipid nanoparticles as vehicles for optogenetic delivery in primary cortical neurons www.mdpi.com/1999-4923/18... #optogenetics, gene therapy without viruses; #BCI #NeuroTech

The vOICe vision BCI 🧠🇪🇺Dec 29

Evaluation of lipid nanoparticles as vehicles for optogenetic delivery in primary cortical neurons https://www.mdpi.com/1999-4923/18/1/4 #optogenetics, gene therapy without viruses; #BCI #NeuroTech

The Last American Vagabond Dec 17

DARPA's "Generative Optogenetics" Program Is All That We've Feared & Held Hostage By Geoengineering https://www.thelastamericanvagabond.com/darpa-optogenetics-geoengineering/ #TheDailyWrapUp #DARPA #Optogenetics #Magnetogenetics #Geoengineering

The vOICe vision BCI 🧠🇪🇺Dec 1

#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials www.linkedin.com/pulse/zhongm... using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM

Zhongmou Wins U.S. FDA Clearan...

Zhongmou Wins U.S. FDA Clearance for China’s First Optogenetic Human Trials

ZM-02 becomes the first China-origin optogenetic therapy authorized for U.S.

The vOICe vision BCI 🧠🇪🇺Dec 1

#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials https://www.linkedin.com/pulse/zhongmou-wins-us-fda-clearance-chinas-first-optogenetic-k1vte/ using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM

"By bypassing damaged rod and cones, this mutation-agonistic approach is being developed for advanced retinal diseases, including retinitis pigmentosa and geographic atrophy (GA) in age-related macular degeneration."

Zhongmou Wins U.S. FDA Clearance for China’s First Optogenetic Human Trials

ZM-02 becomes the first China-origin optogenetic therapy authorized for U.S.

The vOICe vision BCI 🧠🇪🇺Nov 28

Advantages of human opsins in optogenetic visual restoration https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1725264/full #optogenetics #BCI #NeuroTech

Frontiers | Advantages of human opsins in optogenetic visual restoration

Optogenetic vision restoration has progressed from proof-of-concept to early clinical testing, yet most programmes rely on microbial channels that demand hig...

Frontiers

The vOICe vision BCI 🧠🇪🇺Nov 28

Advantages of human opsins in optogenetic visual restoration www.frontiersin.org/journals/neu... #optogenetics #BCI #NeuroTech

Frontiers | Advantages of huma...

Frontiers | Advantages of human opsins in optogenetic visual restoration

Optogenetic vision restoration has progressed from proof-of-concept to early clinical testing, yet most programmes rely on microbial channels that demand hig...

Frontiers

Albert Cardona Nov 12

Adam Claridge-Chang and Shiqiang Gao analyse K+ channelrhodopsins:

"both the absolute K+ to Na+ permeability ratio and its stability over time determine the inhibition to activation transition, which limits their utility for silencing neural circuits."

And they found that a single aminoacid mutant, KCR1-C29D, "shows a relatively high and the most stable K+ to Na+ permeability ratio during illumination", better than heavily protein engineered versions.

"Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins", Duan et al. 2025
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509180

#neuroscience #optogenetics #channelrhodopsin