Researches have found that heart failure is associated with genetically controlled decreases in the activitiy of a specific transcription factor (KLF15). CRISPR-based gene activation was successful at reversing this genetic switch in mice.
Summary: https://medicalxpress.com/news/2026-04-gene-falters-heart-failure-crispr.html
Original paper: https://www.nature.com/articles/s41392-026-02593-9
#Science #Health #HeartDisease #HeartFailure #CRISPR
A single gene switch falters in heart failure—and CRISPR can revive it
In heart failure, the heart can no longer supply the body with enough blood. The condition often develops over many years, for example, due to high blood pressure or other long-term strain on the heart muscle. At first, the heart tries to compensate for this extra workload by working harder, which causes it to enlarge. Over the long term, however, this adaptation leads to structural changes in the heart tissue, and the heart's pumping function progressively deteriorates. Until now, it has been largely unclear which processes occur in the heart muscle during this process and can be specifically targeted for treatment.
On Mar 26, 1973:
#NoëlCoward, English
#playwright (Hay Fever; Private Lives),
#director (In Which We Serve -1942 Academy Award), actor and
#singer, died of
#heartfailure at 73.
#RIP 💔🕊️
Some people bring home souvenirs. I bring home cardiology printouts. One “routine” report showed the day my heart tried improvising without consent—and what it taught me about denial, limits, and the lie of “I’m fine.”
#ChronicIllness #HeartFailure https://thoughtswhilesurvivingchronicillness.buzzsprout.com/2548730/episodes/18716049
When My Heart Rebelled for Two Minutes—and My AICD Decided to Stay Employed - Thoughts While Surviving Chronic Illness: Ramblings From a Chef Whose Body Constantly Rebels
Some people collect souvenirs when they travel. I collect medical printouts. One routine cardiology visit handed me a neat little report, the kind that looks boring until you realize it’s basically a receipt for a moment your body tried to freesty...
Visceral Fat Raises Heart Failure Risk Independently of BMI
📰 Original title: Belly fat linked to heart failure risk even in people with normal weight
🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅
View full AI summary: https://killbait.com/en/visceral-fat-raises-heart-failure-risk-independently-of-bmi/?redirpost=5343ee25-dcc5-44c6-aeee-081ec94f1566
#health #visceralfat #heartfailure #inflammation
Visceral Fat Raises Heart Failure Risk Independently of BMI
New research presented at the American Heart Association’s EPI|Lifestyle Scientific Sessions 2026 highlights the link between belly fat, also known as visceral fat, and the risk of heart failure…
On 3 March 1993:
#AlbertSabin, Polish American
#physician who invented the oral polio vaccine, died of
#heartfailure at 86.
#RIP 🕯️
Well-planned
#plantbased diets link to lower risk of
#heartfailure, while less healthy plant-based
#diets link to higher risk—findings of a prospective study (190k participants, ~13 y follow-up) that are also in line with dietary guidelines:
doi.org/10.3389/fnut... #Nutrition #Health #HeartHealthFrontiers | Adherence to plant...
Frontiers | Adherence to plant-based diet and risk of heart failure among middle-aged and older population
BackgroundPlant-based diets have been demonstrated to be associated with lower risk of several chronic diseases. However, a comprehensive assessment of plant...
In 2007, a routine procedure became heart failure. 19 years later I’m still here—sarcoidosis, an AICD, and a metal box guarding each heartbeat. Miracle, nuisance, survival.
#HeartFailure #Sarcoidosis #AICD #ChronicIllness #Survivorhttps://www.buzzsprout.com/2548730/episodes/18668168
Living With Heart Failure And An AICD - Thoughts While Surviving Chronic Illness: Navigating Life With Sarcoidosis
In 2007, a routine heart procedure turned into a life-changing diagnosis: heart failure. Nineteen years later, I’m still here—living with sarcoidosis, a defibrillator in my chest, and the constant awareness that my next heartbeat might depend on a...
In 2007, a routine heart procedure became heart failure. Nineteen years later, I’m still here—living with sarcoidosis and an AICD, knowing my heartbeat may rely on metal and code. Miracle, nuisance, survival.
#HeartFailure #Sarcoidosis #AICD #ChronicIllness #StillHere
https://www.buzzsprout.com/2548730/episodes/18668168
Living With Heart Failure And An AICD - Thoughts While Surviving Chronic Illness: Navigating Life With Sarcoidosis
In 2007, a routine heart procedure turned into a life-changing diagnosis: heart failure. Nineteen years later, I’m still here—living with sarcoidosis, a defibrillator in my chest, and the constant awareness that my next heartbeat might depend on a...
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