Niente più iniezioni settimanali, penne in frigo ed effetti collaterali da accumulo: in Olanda è appena partito il primo trial al mondo di una terapia genica GLP-1.
Una sola infusione direttamente nel pancreas, guidata da ecografia endoscopica, e il pancreas stesso impara a produrre GLP-1 ogni volta che mangi. 9 pazienti per cominciare (con molta cautela), 5 anni di follow-up, primi dati attesi entro fine 2026.
The GLP-1 supply chain has four independent bottleneck layers — not one.
Most coverage focuses on the CDMOs. But three other layers are binding simultaneously:
1. Peptide synthesis capacity ($5B+ committed, 3-5yr GMP qualification)
2. Glass containment & elastomer components (West Pharma, Stevanato)
3. Autoinjector device assembly (BD, $107B market)
4. Oligonucleotide CDMO (Bachem + Lilly collaboration)
Full analysis: https://durability-curve.pages.dev/ghost/writing/the-4-hidden-bottlenecks-in-the-glp-1-supply-chain/
So, I switched to an oral Wegovy tablet from a compound GLP-1 injectable a few weeks ago, and it's interesting.
The injectable made me get full faster. With Wegovy, I don't seem to get full faster, but I stay full for much longer, so if I eat a big lunch, I'm not hungry for dinner and end up snacking on a banana, peanuts or chips instead.
Even if I never lose another pound, not feeling hungry all the time is absolutely wonderful.
Medicare Initiates Temporary Program for GLP-1 Weight Loss Drugs
Medicare's new GLP-1 Bridge program will offer eligible seniors weight loss drugs for $50/month starting July 1, 2026. Find out who qualifies.
#Medicare #WeightLossDrugs #GLP1 #HealthcareCosts #SeniorHealth
https://newsletter.tf/medicare-weight-loss-drugs-bridge-program-july-2026/
Starting July 1, 2026, Medicare will offer a temporary program for weight loss drugs. Eligible beneficiaries could pay around $50 per month, a significant change from previous coverage limits.
#Medicare #WeightLossDrugs #GLP1 #HealthcareCosts #SeniorHealth
https://newsletter.tf/medicare-weight-loss-drugs-bridge-program-july-2026/
Votre microbiote peut-il imiter les effets du sport ? La découverte fascinante des peptides bactériens RORDEP
Et si une bactérie de votre intestin fabriquait, à votre insu, une molécule qui imite les effets bénéfiques du sport sur la graisse, le sucre sanguin et la thermogenèse ? C'est exactement ce que vient de démontrer une étude publiée dans Nature Microbiology en août 2025, ouvrant un champ inédit : celui des peptides bactériens à action hormonale. D'une bactérie commune à un mime de l'irisine L'équipe de Yang et collaborateurs (groupe Pedersen, Copenhague) a passé au crible […]https://nutricellscience.blog/2026/05/11/rordep-peptides-bacteriens-microbiote-metabolisme/
With millions of people now using GLP-1 drugs such as Wegovy and Zepbound, scientists are racing to find ways to help people retain their weight loss after they stop taking the medication
The Biochemical Beauty of Retatrutide: How GLP-1s Work
#HackerNews #biochemistry #GLP1 #retatrutide #healthscience #drugdiscovery
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