U.S. startup: Genetically Modified babies

Nonsensical and dangerous Übermensch bullshit rearing its ugly head

#genomeediting #GMOkids #eugenics

https://m.youtube.com/watch?v=FJr12rmI8o8&pp=ygUZZnJhbmNlIDI0LCBnZW5vbWUgZWRpdGluZw%3D%3D

US startups explore genome editing in human embryos, raising ethical concerns • FRANCE 24 English

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Meet a hierarchical engineering strategy that improves Casδ-1 #genome editing activity by enhancing its interactions with crRNA, PAM duplex, single-stranded #DNA substrate, and #RNA–DNA heteroduplex.
Read it for free!
https://doi.org/10.1111/jipb.70222
@WileyLifeSci
#PlantSci #CRISPR #JIPB #Botany #OpenAccess #GenomeEditing
Throwback to one of my favorite lab successes from last year! 🧬

Image 1: The most beautiful pellet. Purified plasmid DNA, still in the wash solution, isolated via midiprep from E. coli that I cloned myself.
Image 2: Pure lab chaos. In the middle of the midiprep.
Image 3: The proof. 3158 ng/µL of isolated clean DNA measured on the Nanodrop. Yes, that is much xD
Image 4: And the happy ending. The gel image shows the successful transformation of the gene into Acetobacterium woodii. The new gene was inserted using CRISPR Cas via homologous recombination. Project goal achieved! Two new A. woodii strains that didn't exist before I created them. Proud parent moment. 🧬✂️

The goal of the project is to use A. woodii to produce bioalcohols like ethanol or 2‑butanol (that's my area) directly from CO₂ in the air. 🌍💚

#LabLife #MolecularBiology #CRISPR #GenomeEditing #Microbiology #Science #Research #Plasmid #Biotechnology

Designerbabys: Öffnen wir die Büchse der Pandora? - DocCheck

Eingriffe in die menschliche Keimbahn 🧬 gelten als Tabu. Eine Firma in den USA 🇺🇸 will jetzt zeigen, was mit #GenomeEditing möglich ist. Ist das eine Schande oder eine Chance?
https://www.doccheck.com/de/detail/articles/52559-designerbabys-oeffnen-wir-die-buechse-der-pandora

Designerbabys: Öffnen wir die Büchse der Pandora?

Eingriffe in die menschliche Keimbahn gelten als Tabu. Eine Firma in den USA will jetzt zeigen, was mit Genome Editing möglich ist. Ist das eine Schande oder eine Chance?

DocCheck Community GmbH

Nghiên cứu mới: AI thiết kế enzyme TnpB biến thể tăng cường công nghệ chỉnh sửa gene! Công nghệ AI kết hợp xếp giấy protein và ràng buộc axit amin giúp tạo enzyme hoạt tính vượt trội ở vi khuẩn, thực vật và tế bào người. Phân tích cấu trúc Cryo-EM cho thấy cách liên kết mới tăng tính ổn định. Mở ra tiềm năng vượt qua giới hạn sinh học tự nhiên cho thiết kế enzyme RNA-dẫn. 🧬✨ #CRISPR #ChỉnhSửaGene #AI #TựĐộngHóa #GenomeEditing #BộXâyEnzym

https://www.reddit.com/r/singularity/comments/1pi9zmd/st

Filigranes Zusammenspiel

In Kalifornien wurde mithilfe neuer Gentechnik ein Reis entwickelt, der stickstoffbindende Bakterien anlockt – um den Einsatz von Kunstdünger zu verringern. Klingt sinnvoll. Doch eine Freisetzung solcher Pflanzen könnte ökologische Folgen haben.
Mehr dazu im GID #274
Artikel: „Filigranes Zusammenspiel“ von Franziska Koller


Jetzt GID bestellen und weiterlesen:
https://www.gen-ethisches-netzwerk.de/publikationen/gid/274

#NGT #Reis #GenomeEditing #CRISPR #Landwirtschaft #Umwelt #GIDMagazin

Pronatalismus Reloaded — Rechte Ideologie mit Hightech-Update

Gen-ethisches Netzwerk e.V.

Laschere Regeln für neue Gentechnik? Kein weißer Rauch in Sicht.

Wie sollen Pflanzen aus neuen Genom-Editing-Verfahren künftig zugelassen und gekennzeichnet werden? Noch herrscht Uneinigkeit über Regeln, Verantwortung und Transparenz.

Mehr im Artikel „Kein weißer Rauch in Sicht“ von Judith Düesberg im GID #274:
🔗 https://gen-ethisches-netzwerk.de/biopatente/genome-editing/274/kein-weisser-rauch-sicht

#EU #Gentechnik #GenomeEditing #CRISPR #GIDMagazin

Kein weißer Rauch in Sicht

Wie sollen die neuen Gentechniken reguliert werden? Dazu herrscht Uneinigkeit zwischen den EU-Institutionen und in der deutschen Bundesregierung. Strittige Punkte sind die Kennzeichnung und Patentierbarkeit. Ein Kompromiss scheint in weiter Ferne.

Gen-ethisches Netzwerk e.V.

🧬 Can controlling PARP1 turn CRISPR from a gene scissor into a gene sculptor?

🔗 Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.001

📚 CSBJ: https://www.csbj.org/

#CRISPR #GenomeEditing #Genomics #DNARepair #PARP1 #GeneticEngineering #MolecularBiology #GeneTherapy #CellBiology #SyntheticBiology #TherapeuticEditing

Scientists just fixed a brain’s memory gene with CRISPR — and the brain started learning again.

In a breakthrough experiment on mice, researchers identified a single faulty gene linked to memory loss and cognitive decline. By using CRISPR gene-editing, they precisely repaired the defect inside live brain cells. To their surprise, the animals began regaining learning ability within weeks.

The gene in question controls how neurons form connections, which are essential for memory storage. When it malfunctions, brain circuits weaken, leading to memory impairment similar to conditions like Alzheimer’s disease. Correcting it allowed neurons to re-establish stronger connections, restoring lost brain function.

This experiment marks one of the first times gene editing has directly improved higher brain functions rather than just fixing physical traits. The edited mice performed better in mazes, recognition tests, and pattern recall, showing a measurable recovery in cognitive performance.

If such results can one day be translated to humans, it could open the door to powerful new treatments for neurodegenerative diseases. Instead of drugs that only slow symptoms, doctors may be able to reverse the genetic roots of memory decline.

Of course, challenges remain: editing genes in the human brain is risky, requiring precision delivery systems that won’t harm surrounding tissue. Long-term safety and ethical questions will also be central before any clinical use.

Still, this is a powerful glimpse into what medicine could become — not just treating memory loss, but restoring the brain’s ability to learn itself.

Neuroscience & Memory
#Neuroscience #MemoryResearch #BrainHealth #CognitiveScience #MemoryRestoration #Neuroplasticity #BrainFunction #CognitiveRecovery #LearningScience

Gene Editing & CRISPR
#CRISPR #GeneEditing #GeneticTherapy #GenomeEditing #MolecularMedicine #GeneTherapy #Genomics #PrecisionMedicine #Neurogenetics

🧬 ✂️ 🌱 Call for papers for our upcoming special issue on #Cas12 mediated #GenomeEditing in #plantscience! Submission deadline November 30, 2025.
@wileyplantsci
(Thanks to our publisher, Wiley, for the spiffy graphic)
Learn more here: https://onlinelibrary.wiley.com/page/journal/17447909/homepage/call-for-papers/si-2025-000295
#botany