Postdoctoral researcher
Memorial Sloan Kettering Cancer Center
Postdoc position at Memorial Sloan Kettering in New York to study biochemical and structural mechanisms of DNA replication.
See the full job description on jobRxiv: https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-researcher/
#biochemistry #cryoEM #DNAReplication #genomebiology #ScienceJo...
https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-researcher/?fsp_sid=13200
Archaeal organisms possess Cdc45 and GINS homologs that are likely to serve similar functional roles, but their structural interactions with the MCM helicase and hence their mechanism of MCM activation are not as well understood as for their eukaryotic counterparts. We present the crystal structure of the S. solfataricus GINS tetrameric complex and illustrate that a subdomain would need to move to accommodate known archaeal GINS-complex interactions and to generate an S. solfataricus CMG complex analogous to that of eukaryotes.
Scientists filmed DNA unzipping in real-time! This breakthrough could revolutionize cancer and virus treatment. #DNAReplication #CancerResearch #BiotechInnovation
Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments
https://www.sciencedaily.com/releases/2025/03/250320144758.htm
https://le.ac.uk/news/2025/march/dna-helix-microscopy-cancer
* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level
* reveals how cells begin crucial process of copying their genetic material
Structural dynamics of DNA unwinding by a replicative helicase
https://www.nature.com/articles/s41586-025-08766-w#Sec25
#cancer #MolecularGenetics #StructuralBiology #DNAreplication #DNAhelicase
Scientists have captured the first detailed 'molecular movie' showing DNA being unzipped at the atomic level -- revealing how cells begin the crucial process of copying their genetic material.
The crystal structure of proliferating cell nuclear antigen 1 from the thermophilic archaeon A. pernix was determined at 2.00 Å resolution. This crystal structure revealed unique features in the N-terminus, including a PIP-box-like sequence, suggesting potential interactions with other proliferating cell nuclear antigens.
Understanding DNA Metabolism: A Complex Dance of Life
#DNA, #DNAMetabolism, #DNARepair, #DNAReplication, #Metabolis, #Tramsciption #Genetics DNA, the blueprint of life, holds the key to understanding the complexity of living organisms. Its structure, composed of nucleotide…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
https://micrordt.wordpress.com/2024/05/15/understanding-dna-metabolism-a-complex-dance-of-life/
Unveiling the Hidden Secrets of Life through Bioinformatics
#Bioinformatics, #DNA, #DNAIsolation, #DNARecombination, #DNAReplication, #DNASeperation, #DNASequence, #Genomics, #StructuralBiology #Bioinformatics Introduction: In the age of information, the world of biology has undergone a revolutionary transformation. The decoding of the human…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
Unraveling the Mechanisms: Regulation of DNA Replication in Bacterial Cells
#Bacteria, #CellCycle, #DNA, #DNAReplication, #DnaA, #OriC, #RegulatoryProteins, #Replication #Genetics, #MolecularBiology DNA replication is a fundamental process in all living organisms, ensuring the faithful transmission of genetic information from one generation to the next. In bacterial cells, where simplicity meets efficiency…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs…
#Bacteria, #CellCycle, #DNA, #DNAReplication, #DnaA, #OriC, #RegulatoryProteins, #Replication #Genetics, #MolecularBiology DNA replication is a fundamental process in all living organisms, ensuring…
DNA Repair
#DNA, #DNARecombination, #DNARepair, #DNAReplication, #DNASequence, #Proofreading #Genetics DNA is most important molecule for working of cell. Although it directly not take part in metabolic pathways, but it keep…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
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