PLOS BiologySep 17, 2024
Apicomplexan #parasite division: @MGissot &co show that the #phosphatase TgPP1 in #Toxoplasma regulates the #CellCycle & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins #PLOSBiology https://plos.io/3XwMYgj
PP1 phosphatase controls both daughter cell formation and amylopectin levels in Toxoplasma gondii

Rapid division and biomass production are important for apicomplexan parasite virulence. This study shows that the phosphatase TgPP1 in Toxoplasma gondii regulates the cell cycle and amylopectin accumulation by dephosphorylating inner membrane complex and starch-binding domain proteins.

katch wreckMar 9, 2024

"We show that migrating #neurons in mice possess a growth cone at the tip of their leading process, similar to that of #axons, in terms of the #cytoskeletal dynamics and functional responsivity through protein tyrosine #phosphatase receptor type sigma (PTPσ). Migrating-neuron growth cones respond to chondroitin sulfate (CS) through PTPσ and collapse, which leads to inhibition of #neuronal migration."

https://www.nature.com/articles/s41467-024-45825-8

Identification of the growth cone as a probe and driver of neuronal migration in the injured brain - Nature Communications

Structure and functions of the tip of migratory neurons remain elusive. Here, the authors show that the PTPσ-expressing growth cone senses extracellular matrix changes and drives neuronal migration in the injured brain, leading to the functional recovery.

Nature
CellBioNewsJan 11, 2024

Researchers profile two elusive #proteins critical for healthy #cell #division.

#phosphatase #FAM122A #ARPP19

https://phys.org/news/2024-01-profile-elusive-proteins-critical-healthy.html

Researchers profile two elusive proteins critical for healthy cell division

The cells in our bodies constantly divide and renew themselves. But if division goes wrong, cancer or other diseases can result. Now, University of Connecticut researchers have profiled two elusive proteins critical for healthy cell division. They report their results in the Dec. 20 issue of Nature.

Phys.org
The EMBO JournalSep 15, 2023

#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics

#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al

https://www.embopress.org/doi/full/10.15252/embj.2022112630

The EMBO JournalMar 31, 2023
The EGFR #phosphatase RPTPγ is a #redox-regulated suppressor of promigratory signaling
Maitreyi Joshi, Philippe Bastiaens et al show that #RPTPγ is coupled to autocatalytic, ligandless #EGFR #phosphorylation by a ROS-mediated toggle-switch, enabling ultrasensitive EGFR activation at the plasma membrane
https://www.embopress.org/doi/10.15252/embj.2022111806
StructBiolCommunicationsJan 18, 2023
The first serial synchrotron crystallography structure of apo PTP1B indicates a degree of allosteric decoupling that adds nuance to the previously reported paradigm of allostery in this protein #XRayCrystallography #Phosphatase #Allostery #openaccess https://doi.org/10.1107/S2053230X22011645
Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B

The first serial synchrotron crystallographic structure of apo PTP1B is reported and the conformational heterogeneity at several allosteric sites is compared with that seen in prior structures.

Acta Crystallographica Section F
The EMBO JournalJan 5, 2023

Happy New Year 2023!
Our first issue brings:

#Calreticulin conformation changes in cold response

Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells

#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging

#Microglial TNFα and cortical protein #phosphorylation during #sleep

...and more:
https://www.embopress.org/toc/14602075/2023/42/1