Advances in gasdermin activation, regulation, and targeted drug development
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d4048752e107">Proteins of the gasdermin family are executors of pyroptosis. Upon cleavage-dependent/independent
activation, gasdermins form pores on the cell membrane, which damage the integrity
of the cell membrane and lead to pro-inflammatory cellular content release and lytic
cell death. The role of gasdermin in pyroptosis-associated diseases, such as allergic
diseases, neurologic disorders, infections, and cancer, showcases the tremendous therapeutic
potential of targeting gasdermin. New insights into non-pyroptotic functions continue
to further our understanding of gasdermin. Herein we review current knowledge of the
gasdermin family, demonstrating the mechanism of activation, downstream effects, and
regulatory mechanisms. We also discuss the association with pyroptosis-associated
diseases and the functions beyond pyroptosis, shedding light on the broader roles
in various pathologic processes. Furthermore, we summarize the advances in the development
of targeted agonists and inhibitors with strategies for developing pyroptosis-based
anti-tumor therapies.
</p>
ER stress induces #caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with #herpes simplex #virus type 2
#HSV type 2 infection promotes #neuronal #celldeath and #inflammatory responses via #ERstress-dependent #gasdermin E activation.
Søren Paludan and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2022113118
Characterization of
#Gasdermin E-mediated
#pyroptosis in the basal chordate
#amphioxus reveals that
#GSDME is transcriptionally regulated by IRF1/8, involved in bacteria-induced tissue damage, and inhibited by
#caspase inhibitor
#PLOSBiology https://plos.io/3p6klcm
Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis
Characterization of Gasdermin E-mediated pyroptosis in the basal chordate amphioxus reveals that it is transcriptionally regulated by IRF1/8, involved in bacteria induced tissue damage, and inhibited by caspase inhibitor.
Characterization of
#Gasdermin E-mediated
#pyroptosis in the basal chordate
#amphioxus reveals that
#GSDME is transcriptionally regulated by IRF1/8, involved in bacteria-induced tissue damage, and inhibited by
#caspase inhibitor
#PLOSBiology https://plos.io/3p6klcmCharacterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis
Characterization of Gasdermin E-mediated pyroptosis in the basal chordate amphioxus reveals that it is transcriptionally regulated by IRF1/8, involved in bacteria induced tissue damage, and inhibited by caspase inhibitor.
Characterization of
#Gasdermin E-mediated
#pyroptosis in the basal chordate
#amphioxus reveals that
#GSDME is transcriptionally regulated by IRF1/8, involved in bacteria-induced tissue damage, and inhibited by
#caspase inhibitor
#PLOSBiology https://plos.io/3p6klcmCharacterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis
Characterization of Gasdermin E-mediated pyroptosis in the basal chordate amphioxus reveals that it is transcriptionally regulated by IRF1/8, involved in bacteria induced tissue damage, and inhibited by caspase inhibitor.
Same protein, different shape explains protein's effectiveness against bacteria
Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.
Happy New Year 2023!
Our first issue brings:
#Calreticulin conformation changes in cold response
Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells
#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging
#Microglial TNFα and cortical protein #phosphorylation during #sleep
...and more:
https://www.embopress.org/toc/14602075/2023/42/1
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