CellBioNewsScientists uncover mechanism preserving #centromere during #cell_division.
#mitosis #PLK1 #Mis18 #CENP_A #HJURP #phosphorylation_cascade
https://phys.org/news/2024-09-scientists-uncover-mechanism-centromere-cell.html
Ron Beavis ❌A GPMDB ubiquitination PTM diagram for human polo like kinase 1 (#PLK1:p). This kinase is produced during G1. It is part of the mitosis coordination system that has be ubiquitylated by the anaphase promoting complex and removed for the process to proceed to completion. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467358). #proteomics #anapc
The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression
The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase, facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining genomic stability. Many APC substrates have been observed overexpressed in multiple cancer ...
The EMBO Journal#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al