https://youtu.be/yqeUH4RsJp8?si=SkolqnGxO96VVaVI

Amazingly clear lectures for understanding Machine Learning protein structure prediction!

Part I - Lucid overview of why different ML algos map best to bio structures

Part II - Protein 3D structure boils down to well-informed placement of backbone triangles, from amino acid co-evolution

Part III - Where to now for systems biology? We've gone gene -> network but skipped the machines

Will be exciting when chemical interaction constraints are incorporated!

#OpenFold

@xtaldave @strucbio

OpenFold is a big deal. And a great showcase for free open source software, enabling scientists to improve on each other's work in the best scientific tradition.

Source code: https://github.com/aqlaboratory/openfold

Open data for training: https://registry.opendata.aws/openfold/

#OpenFold #FOSS #StructuralBiology #CryoEM

Currently testing Folding Playground

A one-step solution for comparing #alphafold #omegafold #esmfold and #openfold #AI #protein #structure

https://www.sphinxbio.com/post/folding-playground

OpenFold, a fast, memory-efficient, and trainable implementation of AlphaFold2.

https://www.biorxiv.org/content/10.1101/2022.11.20.517210v3

#Science #ProteinStructure #StructuralBiology #MachineLearning #AlphaFold #OpenFold

Reading #AlphaFold2 and #OMSF #OpenFold code is great but with #protein #molecules in your hands you feel it better. Designing the kit in #FreeCAD ensures you know bond lengths and angles etc. So I spent few days learning and printing. The kit is optimized for protein #folding, single bond rotates but can be fixed in #peptide bond, it keeps shape even before adding #hydrogen #bonds in #alphahelix (or pair #RNA bases by H-bond).

Print your #kit and enjoy #biochemistry!

https://www.printables.com/model/457984-molecules-for-protein-folding

Begun, the Fold wars have.
#alphafold #openfold

https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1.full?utm_source=twitter&utm_medium=social&utm_campaign=tweepsmap-dailytwitter