New protein-folding AI vastly expands on Alphafold's efforts

The new open-source atlas, generated by an AI tool called ESMFold2, vastly increases the known protein universe

Scientific American
Makes sense. I found this telling: timesofindia.indiatimes.com/technology/t... " #DemisHassabis had a plan. #CureCancer. Crack #ProteinFolding. Use Al as a scientific instrument, not a consumer product." #FailedToLoadBlob
Google AI CEO Demis Hassabi on how ChatGPT 'launch' in November 2022 changed everything for AI labs, and not for good; says: It started a dangerous... - The Times of India

Tech News News: Demis Hassabis had a plan. Cure cancer. Crack protein folding. Use AI as a scientific instrument, not a consumer product. Then ChatGPT launched in Nov.

The Times of India

Pipeline release! nf-core/proteinfold v2.0.0 - Montseny Brook Newt!
Protein 3D structure prediction pipeline
Please see the changelog: https://github.com/nf-core/proteinfold/releases/tag/2.0.0

#alphafold2 #colabfold #esmfold #proteinfoldprediction #proteinfolding #proteinsequences #proteinstructure #nfcore #openscience #nextflow #bioinformatics

Release Montseny Brook Newt · nf-core/proteinfold

[2.0.0] - 2026-03-27 Enhancements & fixes [#177] - Fix typo in some instances of model preset alphafold2_ptm. [PR #178] - Enable running multiple modes in parallel. [#179] - Produce an interactive...

GitHub
`Surprisingly..extracted diffusion coefficient at the free energy barrier on the number of native contacts coordinate increases with protein length. This facilitation..in larger proteins is explained by increased cooperative native contact formation during folding, which reduces the roughness of the energy landscape... evolutionary optimization of the energy landscape..more efficient for protein folding than for other biomolecular processes`
https://doi.org/10.1103/2q9m-4scc
#proteinFolding #biophysics

From child prodigy to a race to be the one that puts humans in a zoo. Great look into our current trajectory. Who will wield the stick?

https://www.tribecafilm.com/films/thinking-game-2024

https://youtu.be/d95J8yzvjbQ

#DemisHassabis #AGI #AI #LLM #DeepMind #Google #Geopolitics #ProteinFolding #Science #ThinkingGame #MachineLearning #Energy

The Thinking Game | 2024 Tribeca Festival | Tribeca

The Thinking Game chronicles the extraordinary life of visionary scientist Demis Hassabis and his relentless quest to solve the enigma of artificial general intelligence. After the Premiere Screening: A conversation with CEO and co-founder of Google DeepMind Demis Hassabis, and Director Greg Kohs, moderated by Darren Aronofsky.

Tribeca
When Google restricted AlphaFold 3's commercial use, three MIT PhD students rebuilt the protein folding model in four months. Their open-source version, Boltz-1, now has $28M in funding and a Pfizer partnership. The move highlights tensions between proprietary AI research and scientific openness in drug discovery infrastructure. #OpenScience #ProteinFolding #AIResearch https://www.implicator.ai/when-google-locked-the-door-three-mit-students-picked-the-lock/
When Google Locked the Door, Three MIT Students Picked the Lock

Boltz raised $28M to build open-source AI drug discovery tools. Their bet: free models plus pharma partnerships beats Google's locked-down AlphaFold 3.

Implicator.ai

Five years after AlphaFold reshaped protein folding, its open‑source spirit lives on in Gemini 2.0 – an AI co‑scientist that can argue hypotheses with a principal investigator. Could an agentic system become a true research partner? Dive into the debate and see how open science fuels the next leap. #AlphaFold #Gemini2 #AgenticSystem #ProteinFolding

🔗 https://aidailypost.com/news/alphafold-marks-5-years-new-gemini-20-ai-coscientist-debates

How NVIDIA Turned 'Gaming GPUs Go Brrr' Into 'Actually We Can Read The Language of Life Now' (Part 1 of 2)

A deep, intuitive dive into why proteins are insanely complex, how folding defines life and disease, and how AI like AlphaFold finally cracked biology’s hardest problem.

Trust Me, I'm a Scientist
AlphaFold - The Single Most Important AI Breakthrough

YouTube