Mastodawn

This concise briefing highlights how a molecular mechanism—specifically nitric oxide’s influence on TSC2 and the mTOR pathway—may contribute to neurodevelopmental changes associated with autism. For clinicians in mental health settings, this underscores the potential for biological factors to intersect with behavioral presentations, informing a biopsychosocial lens and ongoing dialogue about etiology and care planning.

Article Title: Scientists discover a brain signal that may trigger autism’s domino effect

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260307155943 dot htm

Researchers have uncovered a surprising molecular chain reaction in the brain that may play a role in some forms of autism. The study suggests that nitric oxide, a tiny signaling molecule normally involved in fine-tuning communication between brain cells, can sometimes trigger a cascade of changes inside neurons. When nitric oxide activity rises, it can alter a protective protein called TSC2, weakening an important cellular brake and allowing the mTOR pathway, which controls growth and protein production, to become overactive.
via Mind & Brain News -- ScienceDaily https://www dot sciencedaily dot com/news/mind_brain/
March 7, 2026 at 08:28PM

#autism #neuroscience #nitricoxide #mTOR #TSC2

Copy and paste broken link above into your browser and replace "dot" with "." for link to work.

We have to do it this way to avoid display of copyrighted images.

Howard Smith MD, AM Feb 11

Fat Switch Controls Weight Gain And More. Also keeps cholesterol in control and prevents liver damage. #obesity #cholesterol #fat #nitricoxide #scor2
https://www.instagram.com/p/DUl9DtHidW2/

Howard G. Smith MD, AM on Instagram: "Fat Switch Controls Weight Gain And More It is possible that an internal switch in your body can be pushed to stop you from gaining weight. As a bonus, this switch also keeps your cholesterol in control and prevents liver damage. Molecular biologists at Cleveland’s Case Western University have found this switch and report their discovery in the journal Science Signaling. Working in a mouse model, the researchers identified a novel enzyme named ScoR2 that plays a significant role in fat generation. ScoR2, a denitrosylase, enzymatically removes nitric oxide, NO, a molecule that normally reduces fat and cholesterol production. The next research step was deactivating this ScoR2 enzyme. Genetic modification halted enzyme production but the team also developed a drug to block its activity and maintain nitric oxide levels. When the enzyme stopped functioning, treated mice stopped gaining weight, experienced cholesterol lowering, and experienced less liver damage. This ScoR2 blocking experimental medication, if proven safe and effective in humans via randomized, controlled clinical trials, would be a 3-in-1 pill for treatment of obesity, cholesterol-driven cardiovascular disease, and fatty liver disease. Stay tuned! https://www.sciencedaily.com/releases/2026/02/260206012226.htm https://www.science.org/doi/10.1126/scisignal.adv0660 #obesity #cholesterol #fat #nitricoxide #scor2"

0 likes, 0 comments - drhowardsmithreports on February 10, 2026: "Fat Switch Controls Weight Gain And More It is possible that an internal switch in your body can be pushed to stop you from gaining weight. As a bonus, this switch also keeps your cholesterol in control and prevents liver damage. Molecular biologists at Cleveland’s Case Western University have found this switch and report their discovery in the journal Science Signaling. Working in a mouse model, the researchers identified a novel enzyme named ScoR2 that plays a significant role in fat generation. ScoR2, a denitrosylase, enzymatically removes nitric oxide, NO, a molecule that normally reduces fat and cholesterol production. The next research step was deactivating this ScoR2 enzyme. Genetic modification halted enzyme production but the team also developed a drug to block its activity and maintain nitric oxide levels. When the enzyme stopped functioning, treated mice stopped gaining weight, experienced cholesterol lowering, and experienced less liver damage. This ScoR2 blocking experimental medication, if proven safe and effective in humans via randomized, controlled clinical trials, would be a 3-in-1 pill for treatment of obesity, cholesterol-driven cardiovascular disease, and fatty liver disease. Stay tuned! https://www.sciencedaily.com/releases/2026/02/260206012226.htm https://www.science.org/doi/10.1126/scisignal.adv0660 #obesity #cholesterol #fat #nitricoxide #scor2".

Instagram

Stephen Hayes Feb 8

#Diet #FoodAsMedicine #HeartHealth #ReverseCholesterolTransport #NitricOxide Reverse #Atherosclerosis m.youtube.com/watch?v=q2Zj...

BEST Meal to UNBLOCK Your Arte...

BEST Meal to UNBLOCK Your Arteries FAST – Why Don’t More Doctors Talk About This | Senior Health

YouTube

Cytology and Genetics Jan 15

Involvement of Nitric Oxide in γ-Aminobutyric Acid-Induced Cellular Mechanisms of Wheat Seedling Adaptation to Water Deficit - #γaminobutyricacid #nitricoxide #oxidativestress #antioxidantsystem #osmolytes #amylase #droughtresistance #Triticumaestivum #Triticum #wheat #waterdeficit #GABA - https://link.springer.com/article/10.3103/S0095452725060106

Involvement of Nitric Oxide in γ-Aminobutyric Acid-Induced Cellular Mechanisms of Wheat Seedling Adaptation to Water Deficit - Cytology and Genetics

Abstract γ-Aminobutyric acid (GABA) is one of the key stress metabolites involved in the functioning of the plant cell signaling network. However, its functional relationships with main signaling molecules, particularly nitric oxide (NO), are not well understood. This study aimed to determine NO’s involvement in GABA’s stress-protective effect on wheat seedlings (Triticum aestivum L., Etana cultivar) under model drought conditions (13% PEG 6000). Priming grains with a 0.5 mM GABA solution or a 0.1 mM solution of the NO donor sodium nitroprusside (SNP) increased germination energy, seed germination, and water content in seedlings under stressful conditions. Additionally, GABA and SNP treatment mitigated the inhibitory effect of drought on the accumulation of root and shoot biomass. Osmotic stress increased NO content in shoots, and priming with GABA and SNP enhanced this effect. Treatment with the nitric oxide scavenger methylene blue (MB, 0.1 mM) eliminated the increase in NO content caused by stress or GABA action. MB also negated the positive effects of GABA on growth processes. Under the action of GABA and SNP, total amylase activity in grains and soluble carbohydrate content in shoots increased under stressful conditions; MB eliminated GABA’s effect on these parameters. Under the model drought, the content of oxidative stress markers (superoxide anion radical, hydrogen peroxide, and malondialdehyde) increased in shoots, but pretreatment of grains with GABA or SNP significantly reduced these effects. Osmotic stress caused an increase in activity of catalase and guaiacol peroxidase in shoots. Preliminary priming with GABA, SNP, and MB did not affect the nature of the changes in activity of these antioxidant enzymes caused by model drought. Meanwhile, superoxide dismutase activity remained unchanged following exposure to the model drought; however, pretreatment seeds with GABA, SNP, and MB increased the enzyme activity. Priming seeds with GABA and SNP increased the total content of phenolic compounds in shoots and preserved the anthocyanin pool under stressful conditions, while MB treatment eliminated these effects. It was concluded that the enhancement of grain germination and seedling growth induced by GABA priming under model drought conditions is largely due to NO-mediated modulation of carbohydrate and secondary compound metabolism.

SpringerLink

what's trending Jan 4

Glucose: The Sticky Killer - Huberman Patrick Suzuki Amen

#nitricoxide #bloodsugar #diabetes

CrazyFitnessGuy Dec 7

The impact of beetroot and beetroot juice on blood pressure has been the focus of numerous studies, with results that continue to affirm beets' cardiovascular benefits

Beetroot juice lowers blood pressure in older people by changing oral microbiome, study shows

The blood pressure-lowering effect of nitrate-rich beetroot juice in older people may be due to specific changes in their oral microbiome, according to the largest study of its kind.

Medical Xpress

RDN Jul 23, 2025

A double-blind randomized crossover study of young (18-30) and old (65-80) adults found that beetroot juice altered the oral microbiome in the older adults only, increased nitric oxide bioavailability, and lowered blood pressure.

Summary: https://medicalxpress.com/news/2025-07-beetroot-juice-lowers-blood-pressure.html

Original paper: https://www.sciencedirect.com/science/article/pii/S0891584925008068

#Science #Health #BloodPressure #CVD #Microbiome #NitricOxide #Beetroot

Beetroot juice lowers blood pressure in older people by changing oral microbiome, study shows

The blood pressure-lowering effect of nitrate-rich beetroot juice in older people may be due to specific changes in their oral microbiome, according to the largest study of its kind.

Medical Xpress