Unlocking mTOR: Intermittent fasting, coffee, and exercise are keys. During exercise, mTOR is suppressed, but after? It springs back!
Follow @biohackingpathway for more
#mTOR #intermittentfasting #coffee #exercise #health #fitness #longevity #biohacking
“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee #ISOGG #geneadons #caffeine #AMPK #MTOR
@unibremen And I saw you also signed More Than Our Rank recently. Well done!
https://inorms.net/more-than-our-rank/
`Here, we show that decreasing the activity of the #mTOR signaling pathway induces human pluripotent stem cells... & blastoids to enter a dormant state with limited proliferation, developmental progression, & capacity to attach to endometrial cells..similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage & is reversible..The pacing of human #blastocyst development has potential implications for reproductive therapies`
review article from 2015:
mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455918/
Chronic pain is a major public health problem with limited treatment options. Opioids remain a routine treatment for chronic pain, but extended exposure to opioid therapy can produce opioid tolerance and hyperalgesia. Although the mechanisms underlying ...
#Lysosomes prove to be quick-change artists with respect to #nutrient availability in the #cell.
https://phys.org/news/2023-10-lysosomes-quick-change-artists-respect-nutrient.html
Lysosomes play an important role in cells and tissues, controlling not only the degradation of substances but also cell division and growth. A team led by Professor Volker Haucke and Dr. Michael Ebner at the FMP has investigated how these two functions are related to nutrient availability in the cell.
Investigating the link between #iron deficiency and regulation of #cell_growth.
#evolution #anabolism #mTOR #KDM3B #LAT3, #RAPTOR
https://phys.org/news/2023-09-link-iron-deficiency-cell-growth.html
New paper! Great collaboration between our group and the @mz at @biozentrum @unibasel - supported by a Sinergia grant of the @snsf_ch.
Aberrant #proteostasis (balance between protein synthesis and degradation, centrally regulated by #mTOR) and mitochondrial dysfunction are two of the most prominent and reproducible processes associated with #aging in skeletal #muscle (and other tissues).
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