Unser Heft 11/2024 ist draußen!
Mit großem Special "Stammzell-#Forschung"
Außerdem:
- #Corona-#Impfstoff;
- Kontroverse #UMAP-Plots;
- #Forschungskandale;
- #Krebsforschung;
- #lncRNA;
- #Protein-#Sequenzierung;
- #Antibiotika-Inkubator
- u.v.m.
Das ganze Heft online: https://www.laborjournal.de/rubric/aktuell/index.php
The GeneCaRNA human gene database is a member of the GeneCards Suite. It presents ~280,000 human non-coding RNA genes, identified algorithmically from ~690,000 RNAcentral transcripts. This expands by ~tenfold the ncRNA gene count relative to other sources. GeneCaRNA thus contains ~120,000 long non-coding RNAs (LncRNAs, >200 bases long), including ~100,000 novel genes. The latter have sparse functional information, a vast terra incognita for future research. LncRNA genes are uniformly represented on all nuclear chromosomes, with 10 genes on mitochondrial DNA. Data obtained from MalaCards, another GeneCards Suite member, finds 1547 genes associated with 1 to 50 diseases. About 15% of the associations portray experimental evidence, with cancers tending to be multigenic. Preliminary text mining within GeneCaRNA discovers interactions of lncRNA transcripts with target gene products, with 25% being ncRNAs and 75% proteins. GeneCaRNA has a biological pathways section, which at present shows 131 pathways for 38 lncRNA genes, a basis for future expansion. Finally, our GeneHancer database provides regulatory elements for ~110,000 lncRNA genes, offering pointers for co-regulated genes and genetic linkages from enhancers to diseases. We anticipate that the broad vista provided by GeneCaRNA will serve as an essential guide for further lncRNA research in disease decipherment.
A new tool for #plant long non-coding #RNA identification.
https://phys.org/news/2024-05-tool-coding-rna-identification.html
Long non-coding RNAs (lncRNAs) are ubiquitous transcripts with crucial regulatory roles in various biological processes, including chromatin remodeling, post-transcriptional regulation, and epigenetic modifications. While accumulating evidence elucidates mechanisms by which plant lncRNAs modulate growth, root development, and seed dormancy, their accurate identification remains challenging due to a lack of plant-specific methods.
Things aren’t always what they seem! Three #preprints together reveal that the lncRNA ivory and its microRNA mir-193, not cortex, drive melanic scale identity in butterflies 🦋
Brilliant preLight from Isabella Cisneros! 🤩
#preLight 👉 https://prelights.biologists.com/highlights/a-long-non-coding-rna-at-the-cortex-locus-controls-adaptive-colouration-in-butterflies-the-ivory-lncrna-regulates-seasonal-color-patterns-in-buckeye-butterflies-a-micro-rna-drives-a-100-million-year-2/
Things aren’t always what they seem! @evolvwing, @FascinatingPupa, @MonteiroLab, and colleagues discover that the lncRNA ivory and its microRNA mir-193, not cortex, drive melanic scale identity in butterflies
New insights on the #transcriptional #regulation of #seed #germination.
https://phys.org/news/2024-03-insights-transcriptional-seed-germination.html
Seeds remain in a dormant state, waiting for the right environmental conditions to germinate, thus increasing the probability of fragile seedling survival. The transition from a dry seed to a vegetative seedling is an irreversible process that requires a near-complete reprogramming of the plant transcriptome. While it is widely accepted that the activation of protein synthesis (translation) from seed-stored mRNAs is an essential step to trigger seed germination, much less was known about the re-initiation of the process of transcription.
#CRISPRlnc: New #lncRNA-specific #SgRNA design method proposed.
https://phys.org/news/2024-03-crisprlnc-lncrna-specific-sgrna-method.html
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts. Currently, CRISPR/Cas9 is a promising RNA-guided genome editing technology consisting of a Cas9 nuclease and a single-guide RNA (sgRNA). Considering the significant differences between lncRNAs and protein-coding genes, it is necessary to investigate sgRNA design method optimized for lncRNAs.
An interesting finding from Tim Bredy, Rob Spitale & others:
lncRNAs localize to synapses, regulate synaptic activity and behavior!
#lncRNA #RNA #synapse
Synaptic activity controls the extinction of conditioned fear. Here the authors discovered a new way that the brain controls memories of fear: a long noncoding RNA called Gas5 that coordinates the activity of RNA granules in the synaptic compartment.
🥳 Happy to share the publication of the last part of Thomas Roule's Ph.D. at IPS2 on the role of ARES #lncRNA 🧬 in the modulation of Arabidopsis 🌱 root architecture. https://doi.org/10.1002/iub.2761
A great collaboration with the group of Federico Ariel 🧪
Laborjournal
WikiPathways
Paul Gardner
CellBioNews
preLights
The EMBO Journal
Gal Haimovich 😷🔬☣🏳️🌈🏳️⚧
Thomas Blein